Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상훈 | - |
dc.date.accessioned | 2019-12-01T13:08:14Z | - |
dc.date.available | 2019-12-01T13:08:14Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.citation | STEM CELL REPORTS, v. 9, no. 4, page. 1192-1206 | en_US |
dc.identifier.issn | 2213-6711 | - |
dc.identifier.uri | https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(17)30374-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2213671117303740%3Fshowall%3Dtrue | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/115883 | - |
dc.description.abstract | Cultured neural stem/precursor cells (NSCs) are regarded as a potential systematic cell source to treat Parkinson's disease (PD). However, the therapeutic potential of these cultured NSCs is lost during culturing. Here, we show that treatment of vitamin C (VC) enhances generation of authentic midbrain-type dopamine (mDA) neurons with improved survival and functions from ventral midbrain (VM)-derived NSCs. VC acted by upregulating a series of mDA neuron-specific developmental and phenotype genes via removal of DNA methylation and repressive histone code (H3K9m3, H3K27m3) at associated gene promoter regions. Notably, the epigenetic changes induced by transient VC treatment were sustained long after VC withdrawal. Accordingly, transplantation of VC-treated NSCs resulted in improved behavioral restoration, along with enriched DA neuron engraftment, which faithfully expressed midbrain-specific markers in PD model rats. These results indicate that VC treatment to donor NSCs could be a simple, efficient, and safe therapeutic strategy for PD in the future. | en_US |
dc.description.sponsorship | This work was supported by grants from the Medical Research Center (2017R1A5A2015395) and NRF-2017R1A2B2002220, funded by the National Research Foundation of Korea (NRF) of the Ministry of Science and ICT, Republic of Korea. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | CELL PRESS | en_US |
dc.subject | EXPANDED MESENCEPHALIC PRECURSORS | en_US |
dc.subject | NEURAL STEM-CELLS | en_US |
dc.subject | L-ASCORBIC-ACID | en_US |
dc.subject | DOPAMINE NEURONS | en_US |
dc.subject | LONG-TERM | en_US |
dc.subject | RAT MODEL | en_US |
dc.subject | IN-VIVO | en_US |
dc.subject | DIFFERENTIATION | en_US |
dc.subject | NURR1 | en_US |
dc.subject | BRAIN | en_US |
dc.title | vitamin C-induced epigenetic modifications in donor NSCs establish midbrain marker expressions critical for cell-based therapy in Parkinson's disease | en_US |
dc.type | Article | en_US |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.1016/j.stemcr.2017.08.017 | - |
dc.relation.page | 1192-1206 | - |
dc.relation.journal | STEM CELL REPORTS | - |
dc.contributor.googleauthor | Wulansari, Noviana | - |
dc.contributor.googleauthor | Kim, Eun-Hee | - |
dc.contributor.googleauthor | Sulistio, Yanuar Alan | - |
dc.contributor.googleauthor | Rhee, Yong-Hee | - |
dc.contributor.googleauthor | Song, Jae-Jin | - |
dc.contributor.googleauthor | Lee, Sang-Hun | - |
dc.relation.code | 2017007171 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | leesh | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.