Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2019-12-01T10:48:28Z | - |
dc.date.available | 2019-12-01T10:48:28Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.citation | JOURNAL OF CONTROLLED RELEASE, v. 264, page. 24-33 | en_US |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.issn | 1873-4995 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S016836591730768X?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/115785 | - |
dc.description.abstract | Artificial cationic helical peptides possess an enhanced cell-penetrating property. However, their cell-penetrability is not converted by cellular environmental changes resulting in nonspecific uptake. In this study, pH-sensitive anion-donating groups were added to a helical polypeptide to simultaneously achieve tumor targeting and pro-apoptotic activity. The mitochondria-destabilizing helical polypeptide undergoing pH-dependent conformational transitions selectively targeted cancer cells consequently disrupting mitochondrial membranes and subsequently inducing apoptosis. This work presents a promising peptide therapeutic system for cancer therapy. | en_US |
dc.description.sponsorship | This work was financially supported by the KAIST High Risk High Return Project (Project No. N10170020) and by the National Research Foundation (NRF) of Korea (Project No. NRF-2016R1A2B4009619 to Y.C. Kim; NRF-2015R1A2A1A13027811, NRF-2016M3A9B5942352 to C.O. Yun). We thank the Korea Research Institute of Bioscience and Biotechnology (KRIBB) for their confocal laser scanning microscopy and flow cytometry facilities. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | pH-activated helical formation | en_US |
dc.subject | Mitochondrial membrane destabilization | en_US |
dc.subject | Pro-apoptotic activity | en_US |
dc.subject | Cancer targeting and therapy | en_US |
dc.title | Conformation-switchable helical polypeptide eliciting selective pro-apoptotic activity for cancer therapy | en_US |
dc.type | Article | en_US |
dc.relation.volume | 264 | - |
dc.identifier.doi | 10.1016/j.jconrel.2017.08.001 | - |
dc.relation.page | 24-33 | - |
dc.relation.journal | JOURNAL OF CONTROLLED RELEASE | - |
dc.contributor.googleauthor | Lee, DaeYong | - |
dc.contributor.googleauthor | Lee, Soo-Hwan | - |
dc.contributor.googleauthor | Na, Youjin | - |
dc.contributor.googleauthor | Noh, Ilkoo | - |
dc.contributor.googleauthor | Ha, JongHoon | - |
dc.contributor.googleauthor | Yoo, Jisang | - |
dc.contributor.googleauthor | Bang, Hyun Bae | - |
dc.contributor.googleauthor | Park, Jong Hyun | - |
dc.contributor.googleauthor | Jeong, Ki Jun | - |
dc.contributor.googleauthor | Yun, Chae-Ok | - |
dc.relation.code | 2017003061 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | chaeok | - |
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