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Bone Mineral Density According to Dual Energy X-ray Absorptiometry is Associated with Serial Serum Alkaline Phosphatase Level in Extremely Low Birth Weight Infants at Discharge

Title
Bone Mineral Density According to Dual Energy X-ray Absorptiometry is Associated with Serial Serum Alkaline Phosphatase Level in Extremely Low Birth Weight Infants at Discharge
Author
박현경
Keywords
bone mineral density; dual energy x-ray absorptiometry; premature infants
Issue Date
2017-09
Publisher
ELSEVIER TAIWAN
Citation
PEDIATRICS AND NEONATOLOGY, v. 58, no. 3, page. 251-257
Abstract
Background: To examine bone mineral density in extremely low birth weight infants at discharge and investigate whether serial measurements of serum alkaline phosphatase (ALP) and phosphate can predict bone mineralization.Methods: The individuals were 70 preterm infants. Serum calcium, phosphate, and ALP were measured at weekly intervals during admission in extremely low birth weight infants (mean gestational age, 25.3 +/- 2.1 weeks; birth weight, 812.8 +/- 141.1 g). Bone mineral apparent density (BMAD) of the lumbar spine was prospectively evaluated by dual energy X-ray absorptiometry at discharge (n = 70).Results: BMAD was classified as poor (< 25th percentile) at < 0.014 g/cm(3), fair (25th-75th percentile) at < 0.014-0.021 g/cm(3), and good (> 75th percentile) at > 0.021 g/cm(3), based on the distribution of BMAD values in infants with noncomplicated courses of prematurity (n = 43). In a further multivariate analysis, the number of total parenteral nutrition days, phosphate at 2 postnatal weeks and 3 postnatal weeks, and ALP at 4 postnatal weeks and 5 postnatal weeks had an impact on bone mineral density at the lumbar spine, independent of gestational age and body weight. Peak ALP activities exceeding 650 IU/L revealed low bone mineral density with 80% sensitivity and 64% specificity (AUC, 0.70; p = 0.005).Conclusion: Serial measurements of serum ALP and phosphate are associated with decreased bone mineralization by dual energy X-ray absorptiometry at discharge in extremely low birth weight infants. Copyright (C)2016, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.
URI
https://www.pediatr-neonatol.com/article/S1875-9572(16)30180-2/fulltexthttps://repository.hanyang.ac.kr/handle/20.500.11754/115670
ISSN
1875-9572
DOI
10.1016/j.pedneo.2016.05.005
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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