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dc.contributor.author남진우-
dc.date.accessioned2019-11-30T09:06:08Z-
dc.date.available2019-11-30T09:06:08Z-
dc.date.issued2017-09-
dc.identifier.citationONCOTARGET, v. 8, no. 37, page. 61538-61550en_US
dc.identifier.issn1949-2553-
dc.identifier.urihttp://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=18618&path[]=59819-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/115490-
dc.description.abstractTriple-negative breast cancer is characterized by the absence of estrogen and progesterone receptors and human epidermal growth factor receptor 2, and is associated with a poorer outcome than other subtypes of breast cancer. Moreover, there are no accurate prognostic genes or effective therapeutic targets, thereby necessitating continued intensive investigation. This study analyzed the genetic mutation landscape in 70 patients with triple-negative breast cancer by targeted exome sequencing of tumor and matched normal samples. Sequencing showed that more than 50% of these patients had deleterious mutations and homozygous deletions of DNA repair genes, such as ATM, BRCA1, BRCA2, WRN, and CHEK2. These findings suggested that a large number of patients with triple-negative breast cancer have impaired DNA repair function and that therefore a poly ADP-ribose polymerase inhibitor may be an effective drug in the treatment of this disease. Notably, homozygous deletion of three genes, EPHA5, MITF, and ACSL3, was significantly associated with an increased risk of recurrence or distant metastasis in adjuvant chemotherapy-treated patients.en_US
dc.description.sponsorshipThis research was supported by the R&D Program of the Society of the National Research Foundation funded by the Ministry of Science, ICT, and Future Planning (YKS, grant number: NRF-2013M3C8A1078433); a Global Frontier Project grant (YLC, grant number: NRF-M3A6A4-2010-0029795) from the National Research Foundation by the Ministry of Education, Science, and Technology of South Korea; and a National Research Foundation of Korea grant funded by the Ministry of Science, ICT, and Future Planning (YLC, grant number: NRF-2013R1A2A2A01068922).en_US
dc.language.isoen_USen_US
dc.publisherIMPACT JOURNALS LLCen_US
dc.subjecttriple-negative breast canceren_US
dc.subjecttargeted exome sequencingen_US
dc.subjectsingle nucleotide varianten_US
dc.subjectcopy number variationen_US
dc.subjectDNA repair pathwayen_US
dc.titleTargeted exome sequencing of Korean triple-negative breast cancer reveals homozygous deletions associated with poor prognosis of adjuvant chemotherapy-treated patients.en_US
dc.typeArticleen_US
dc.relation.no37-
dc.relation.volume8-
dc.identifier.doi10.18632/oncotarget.18618-
dc.relation.page61538-61550-
dc.relation.journalOncotarget-
dc.contributor.googleauthorJeong, Hae Min-
dc.contributor.googleauthorKim, Ryong Nam-
dc.contributor.googleauthorKwon, Mi Jeong-
dc.contributor.googleauthorOh, Ensel-
dc.contributor.googleauthorHan, Jinil-
dc.contributor.googleauthorLee, Se Kyung-
dc.contributor.googleauthorChoi, Jong-Sun-
dc.contributor.googleauthorPark, Sara-
dc.contributor.googleauthorNam, Seok Jin-
dc.contributor.googleauthorNam, Jin Wu-
dc.relation.code2017036807-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidjwnam-


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