Visceral adipose tissue macrophage-targeted TACE silencing to treat obesity-induced type 2 diabetes
- Title
- Visceral adipose tissue macrophage-targeted TACE silencing to treat obesity-induced type 2 diabetes
- Author
- 김용희
- Keywords
- Adipose tissue macrophage; Visceral adipose tissue; Anti-inflammatory gene delivery; Targeted gene delivery
- Issue Date
- 2017-09
- Publisher
- ELSEVIER SCI LTD
- Citation
- BIOMATERIALS, v. 148, page. 81-89
- Abstract
- Obesity is an increasingly prevalent global health problem. Due to its close relations with metabolic diseases and cancer, new therapeutic approaches for treating obesity and obesity-induced metabolic diseases are required. Visceral white adipose tissue (WAT) has been closely associated with obesity induced inflammation and adipose tissue macrophages (ATMs) are responsible for obesity-induced inflammation by releasing inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6. TNF-alpha converting enzyme (TACE) is a transmembrane enzyme that induces the enzymatic cleavage and release of inflammatory cytokines. In this study, we developed a nonviral gene delivery system consisting of an oligopeptide (ATS-9R) that can selectively target visceral ATMs. In here we shows visceral adipose tissue-dominant inflammatory gene over-expressions in obese mouse and our strategy enabled the preferential delivery of therapeutic genes to visceral ATMs and successfully achieved ATM targeted gene silencing. Finally, ATS-9R-mediated TACE gene silencing in visceral ATMs alleviated visceral fat inflammation and improved type 2 diabetes by reducing whole body inflammation. (C) 2017 Elsevier Ltd. All rights reserved.
- URI
- https://www.sciencedirect.com/science/article/pii/S0142961217306087?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/115485
- ISSN
- 0142-9612; 1878-5905
- DOI
- 10.1016/j.biomaterials.2017.09.023
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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