Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤지희 | - |
dc.date.accessioned | 2019-11-30T04:31:21Z | - |
dc.date.available | 2019-11-30T04:31:21Z | - |
dc.date.issued | 2017-09 | - |
dc.identifier.citation | BMB REPORTS, v. 50, no. 9, page. 472-477 | en_US |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | http://www.bmbreports.org/journal/view.html?doi=10.5483/BMBRep.2017.50.9.124 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/115378 | - |
dc.description.abstract | The transcription repressor Bach2 has been proposed as a regulator of T cell quiescence, but the underlying mechanism is not fully understood. Given the importance of interleukin-2 in T cell activation, we investigated whether Bach2 is a component of the network of factors that regulates interleukin-2 expression. In primary and transformed CD4(+) T cells, Bach2 overexpression counteracted T cell receptor/CD28-or PMA/ionomycin-driven induction of interleukin-2 expression, and silencing of Bach2 had the opposite effect. Luciferase and chromatin immunoprecipitation assays revealed that Bach2 binds to multiple Maf-recognition element-like sites on the interleukin-2 proximal promoter in a manner competitive with AP-1, and thereby represses AP-1-driven induction of interleukin-2 transcription. Thus, this study demonstrates that Bach2 is a direct repressor of the interleukin-2 gene in CD4(+) T cells during the immediate early phase of AP-driven activation, thereby playing an important role in the maintenance of immune quiescence in the steady state. | en_US |
dc.description.sponsorship | We thank Drs Young Dae Yun, Mi-La Cho, and Youn Soo Choi for providing reagents and Yun-Seung Jeong for technical assistance. We thank the Analytical Instrumental Center (Seoul) at Hanyang University for technical support. This work was supported by a NRF grant (NRF-2014R1A2A1A11052070). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | en_US |
dc.subject | Bach2 | en_US |
dc.subject | CD4(+) T cells | en_US |
dc.subject | IL-2 | en_US |
dc.subject | Repressor | en_US |
dc.title | Bach2 represses the AP-1-driven induction of interleukin-2 gene transcription in CD4(+) T cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 9 | - |
dc.relation.volume | 50 | - |
dc.identifier.doi | 10.5483/BMBRep.2017.50.9.124 | - |
dc.relation.page | 472-477 | - |
dc.relation.journal | BMB REPORTS | - |
dc.contributor.googleauthor | Jang, Eunkyeong | - |
dc.contributor.googleauthor | Lee, Hye Rim | - |
dc.contributor.googleauthor | Lee, Geon Hee | - |
dc.contributor.googleauthor | Oh, Ah-Reum | - |
dc.contributor.googleauthor | Cha, Ji-Young | - |
dc.contributor.googleauthor | Igarashi, Kazuhiko | - |
dc.contributor.googleauthor | Youn, Jeehee | - |
dc.relation.code | 2017010823 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jhyoun | - |
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