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Bach2 represses the AP-1-driven induction of interleukin-2 gene transcription in CD4(+) T cells

Title
Bach2 represses the AP-1-driven induction of interleukin-2 gene transcription in CD4(+) T cells
Author
윤지희
Keywords
Bach2; CD4(+) T cells; IL-2; Repressor
Issue Date
2017-09
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Citation
BMB REPORTS, v. 50, no. 9, page. 472-477
Abstract
The transcription repressor Bach2 has been proposed as a regulator of T cell quiescence, but the underlying mechanism is not fully understood. Given the importance of interleukin-2 in T cell activation, we investigated whether Bach2 is a component of the network of factors that regulates interleukin-2 expression. In primary and transformed CD4(+) T cells, Bach2 overexpression counteracted T cell receptor/CD28-or PMA/ionomycin-driven induction of interleukin-2 expression, and silencing of Bach2 had the opposite effect. Luciferase and chromatin immunoprecipitation assays revealed that Bach2 binds to multiple Maf-recognition element-like sites on the interleukin-2 proximal promoter in a manner competitive with AP-1, and thereby represses AP-1-driven induction of interleukin-2 transcription. Thus, this study demonstrates that Bach2 is a direct repressor of the interleukin-2 gene in CD4(+) T cells during the immediate early phase of AP-driven activation, thereby playing an important role in the maintenance of immune quiescence in the steady state.
URI
http://www.bmbreports.org/journal/view.html?doi=10.5483/BMBRep.2017.50.9.124https://repository.hanyang.ac.kr/handle/20.500.11754/115378
ISSN
1976-6696; 1976-670X
DOI
10.5483/BMBRep.2017.50.9.124
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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