Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2019-11-29T21:48:57Z | - |
dc.date.available | 2019-11-29T21:48:57Z | - |
dc.date.issued | 2017-08 | - |
dc.identifier.citation | POSTGRADUATE MEDICAL JOURNAL, v. 93, no. 1102, page. 465-471 | en_US |
dc.identifier.issn | 0032-5473 | - |
dc.identifier.issn | 1469-0756 | - |
dc.identifier.uri | https://pmj.bmj.com/content/93/1102/465 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/115269 | - |
dc.description.abstract | Objectives To systematically review evidence regarding the relationship between circulating interleukin-17 (IL-17) levels and rheumatoid arthritis (RA), and associations between polymorphisms in IL-17 genes and RA susceptibility.Method We performed a meta-analysis of serum/plasma IL-17 levels in patients with RA and controls, and evaluated evidence of associations between the rs2275913, rs3819024, rs4711998 and rs8193036 polymorphisms in IL-17A and the rs763780 and rs2397084 polymorphisms in IL-17F and risk for RA.Results Fourteen studies including 3118 patients with RA and 2725 controls were included. Our meta-analysis revealed that IL-17 levels were significantly higher in the RA group than in the control group (p=3.1x10(-6)). Subgroup analysis using sample size showed increased IL-17 levels in samples from both small (n <= 100) and large (n>100) RA groups (p=1.1x10(-4) and p=0.008, respectively). We found evidence of associations between RA and alleles from the IL-17A rs2275913 and IL-17F rs763780 polymorphisms in Caucasians (p=0.003 and p=0.037, respectively). In addition, we found an association between RA and alleles of the IL-17A rs3819024 polymorphism in the pooled RA cohort compared with matched controls (p=0.033). However, no evidence of association was found between the IL-17F rs2397084, IL-17A rs4711998 and IL-17A rs8193036 polymorphisms and RA susceptibility.Conclusions Our meta-analysis revealed significantly higher circulating IL-17 levels in patients with RA, and found evidence of associations between the IL-17A rs2275913, IL-17F rs763780 and IL-17A rs3819024 polymorphisms and pathogenesis of RA. | en_US |
dc.description.sponsorship | This study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI15C2958). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | BMJ PUBLISHING GROUP | en_US |
dc.subject | INFLAMMATORY CYTOKINES | en_US |
dc.subject | SERUM-LEVELS | en_US |
dc.subject | T-CELLS | en_US |
dc.subject | INTERLEUKIN-17 | en_US |
dc.subject | MECHANISMS | en_US |
dc.subject | INDUCTION | en_US |
dc.subject | ASTHMA | en_US |
dc.subject | GAMMA | en_US |
dc.title | Associations between circulating IL-17 levels and rheumatoid arthritis and between IL-17 gene polymorphisms and disease susceptibility: a meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 1102 | - |
dc.relation.volume | 93 | - |
dc.identifier.doi | 10.1136/postgradmedj-2016-134637 | - |
dc.relation.page | 465-471 | - |
dc.relation.journal | POSTGRADUATE MEDICAL JOURNAL | - |
dc.contributor.googleauthor | Lee, Young Ho | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.relation.code | 2017001442 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
dc.identifier.orcid | http://orcid.org/0000-0003-4658-1093 | - |
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