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dc.contributor.author최미연-
dc.date.accessioned2019-11-29T07:47:35Z-
dc.date.available2019-11-29T07:47:35Z-
dc.date.issued2017-08-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v. 489, no. 4, page. 420-425en_US
dc.identifier.issn0006-291X-
dc.identifier.issn1090-2104-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0006291X17310665?via%3Dihub-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/115233-
dc.description.abstractKetamine shows promise as a therapeutic agent for the treatment of depression. The increased expression of brain-derived neurotrophic factor (BDNF) has been associated with the antidepressant-like effects of ketamine, but the mechanism of BDNF induction is not well understood. In the current study, we demonstrate that the treatment of rats with ketamine results in the dose-dependent rapid upregulation of Bdnf promoter IV activity and expression of Bdnf exon IV mRNAs in rat hippocampal neurons. Transfection of histone deacetylase 5 (HDAC5) into rat hippocampal neurons similarly induces Bdnf mRNA expression in response to ketamine, whereas transfection of a HDAC5 phosphorylation-defective mutant (Ser259 and Ser498 replaced by A1a259 and A1a498), results in the suppression of ketamine-mediated BDNF promoter IV transcriptional activity. Viral-mediated hippocampal knockdown of HDAC5 induces Bdnf mRNA and protein expression, and blocks the enhancing effects of ketamine on BDNF expression in both unstressed and stressed rats, and thereby providing evidence for the role of HDAC5 in the regulation of Bdnf expression. Taken together, our findings implicate HDAC5 in the ketamine-induced transcriptional regulation of Bdnf, and suggest that the phosphorylation of HDAC5 regulates the therapeutic actions of ketamine. (C) 2017 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-2017) and National Research Foundation of Korea (NRF) grant funded by the Ministry of Education, Science and Technology (MEST), Republic of Korea (No. 2016R1A2B2006474; H.S.); and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2016R1A6A3A01007757; M.Y.C).en_US
dc.language.isoen_USen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.subjectKetamineen_US
dc.subjectHDAC5en_US
dc.subjectBDNFen_US
dc.subjectHippocampusen_US
dc.titleKetamine induces brain-derived neurotrophic factor expression via phosphorylation of histone deacetylase 5 in rats.en_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume489-
dc.identifier.doi10.1016/j.bbrc.2017.05.157-
dc.relation.page420-425-
dc.relation.journalBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.contributor.googleauthorChoi, Miyeon-
dc.contributor.googleauthorLee, Seung Hoon-
dc.contributor.googleauthorPark, Min Hyeop-
dc.contributor.googleauthorKim, Yong-Seok-
dc.contributor.googleauthorSon, Hyeon-
dc.relation.code2017001220-
dc.sector.campusS-
dc.sector.daehakRESEARCH INSTITUTE[S]-
dc.sector.departmentHBRI-
dc.identifier.pidliebemy-
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