Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 양철수 | - |
dc.date.accessioned | 2019-11-29T04:47:35Z | - |
dc.date.available | 2019-11-29T04:47:35Z | - |
dc.date.issued | 2017-08 | - |
dc.identifier.citation | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v. 61, no. 9, Article no. e02752-16 | en_US |
dc.identifier.issn | 0066-4804 | - |
dc.identifier.issn | 1098-6596 | - |
dc.identifier.uri | https://aac.asm.org/content/61/9/e02752-16 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/115149 | - |
dc.description.abstract | Mycobacterium abscessus is a highly pathogenic drug-resistant rapidly growing mycobacterium. In this study, we evaluated the in vitro, intracellular, and in vivo activities of LCB01-0371, a novel and safe oxazolidinone derivative, for the treatment of M. abscessus infection and compared its resistance to that of other oxazolidinone drugs. LCB01-0371 was effective against several M. abscessus strains in vitro and in a macrophage model of infection. In the murine model, a similar efficacy to linezolid was achieved, especially in the lungs. We induced laboratory-generated resistance to LCB01-0371; sequencing analysis revealed mutations in rplC of T424C and G419A and a nucleotide insertion at the 503 position. Furthermore, LCB01-0371 inhibited the growth of amikacin-, cefoxitin-, and clarithromycin-resistant strains. Collectively, our data indicate that LCB01-0371 might represent a promising new class of oxazolidinones with improved safety, which may replace linezolid for the treatment of M. abscessus. | en_US |
dc.description.sponsorship | This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant HI15C0395), and the National Research Foundation of Korea (grant 2016R1D1A1A02937214) from research funds of Chungnam National University and funds of the research promotion program, Gyeongsang National University, 2016. Jinsun Jeong was supported by the BK21plus program through the National Research Foundation (NRF), funded by the Ministry of Education of Korea. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | AMER SOC MICROBIOLOGY | en_US |
dc.subject | drug resistance | en_US |
dc.subject | LCB01-0371 | en_US |
dc.subject | Mycobacterium abscessus | en_US |
dc.subject | oxazolidinone | en_US |
dc.title | Activity of LCB01-0371, a Novel Oxazolidinone, against Mycobacterium abscessus | en_US |
dc.type | Article | en_US |
dc.relation.no | 9 | - |
dc.relation.volume | 61 | - |
dc.identifier.doi | 10.1128/AAC.02752-16 | - |
dc.relation.page | 1-15 | - |
dc.relation.journal | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | - |
dc.contributor.googleauthor | Kim, Tae Sung | - |
dc.contributor.googleauthor | Choe, Jin Ho | - |
dc.contributor.googleauthor | Kim, Young Jae | - |
dc.contributor.googleauthor | Yang, Chul-Su | - |
dc.contributor.googleauthor | Kwon, Hyun-Jin | - |
dc.contributor.googleauthor | Jeong, Jinsun | - |
dc.contributor.googleauthor | Kim, Guehye | - |
dc.contributor.googleauthor | Park, Da Eun | - |
dc.contributor.googleauthor | Jo, Eun-Kyeong | - |
dc.contributor.googleauthor | Cho, Young-Lag | - |
dc.relation.code | 2017002020 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | chulsuyang | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.