Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 류재숙 | - |
dc.date.accessioned | 2019-11-28T07:37:26Z | - |
dc.date.available | 2019-11-28T07:37:26Z | - |
dc.date.issued | 2017-08 | - |
dc.identifier.citation | KOREAN JOURNAL OF PARASITOLOGY, v. 55, no. 4, page. 375-384 | en_US |
dc.identifier.issn | 0023-4001 | - |
dc.identifier.issn | 1738-0006 | - |
dc.identifier.uri | http://parasitol.kr/journal/view.php?doi=10.3347/kjp.2017.55.4.375 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/115100 | - |
dc.description.abstract | Trichomonas vaginalis is a pathogen that triggers severe immune responses in hosts. T. vaginalis alpha-actinin 2, Tv alpha-actinin 2, has been used to diagnose trichomoniasis. This study was undertaken to examine the role of Tv alpha-actinin 2 as an antigenic molecule to induce immune responses from humans. Western blot analysis using anti-Tv alpha-actinin 2 anti-bodies indicated its presence in the secreted proteins of T. vaginalis. ELISA was employed to measure cytokine production by vaginal epithelial cells, prostate cells, mouse dendritic cells (DCs), or T cells stimulated with T. vaginalis or Tv alpha-actinin 2 protein. Both T. vaginalis and rTva-actinin 2 induced cytokine production from epithelial cell lines, including IL-10. Moreover, CD4(+)CD25(-) regulatory T cells (Treg cells) incubated with rTv alpha-actinin 2-treated DCs produced high levels of IL-10. These data indicate that Tv alpha-actinin 2 modulates immune responses via IL-10 production by Treg cells. | en_US |
dc.description.sponsorship | This work was supported by the Basic Science Research Programs (NRF-2016R1A6A3A11934451) through the National Research Foundation (NRF) of the Ministry of Education, Science, and Technology, Korea. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN SOC PARASITOLOGY | en_US |
dc.subject | Trichomonas vaginalis | en_US |
dc.subject | alpha-actinin 2 | en_US |
dc.subject | Treg cell | en_US |
dc.subject | interleukin-10 (IL-10) | en_US |
dc.title | Trichomonas vaginalis alpha-Actinin 2 Modulates Host Immune Responses by Inducing Tolerogenic Dendritic Cells via IL-10 Production from Regulatory T Cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 55 | - |
dc.identifier.doi | 10.3347/kjp.2017.55.4.375 | - |
dc.relation.page | 375-384 | - |
dc.relation.journal | KOREAN JOURNAL OF PARASITOLOGY | - |
dc.contributor.googleauthor | Lee, Hye-Yeon | - |
dc.contributor.googleauthor | Kim, Juri | - |
dc.contributor.googleauthor | Ryu, Jae-Sook | - |
dc.contributor.googleauthor | Park, Soon-Jung | - |
dc.relation.code | 2017007614 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jsryu | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.