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Trichomonas vaginalis alpha-Actinin 2 Modulates Host Immune Responses by Inducing Tolerogenic Dendritic Cells via IL-10 Production from Regulatory T Cells

Title
Trichomonas vaginalis alpha-Actinin 2 Modulates Host Immune Responses by Inducing Tolerogenic Dendritic Cells via IL-10 Production from Regulatory T Cells
Author
류재숙
Keywords
Trichomonas vaginalis; alpha-actinin 2; Treg cell; interleukin-10 (IL-10)
Issue Date
2017-08
Publisher
KOREAN SOC PARASITOLOGY
Citation
KOREAN JOURNAL OF PARASITOLOGY, v. 55, no. 4, page. 375-384
Abstract
Trichomonas vaginalis is a pathogen that triggers severe immune responses in hosts. T. vaginalis alpha-actinin 2, Tv alpha-actinin 2, has been used to diagnose trichomoniasis. This study was undertaken to examine the role of Tv alpha-actinin 2 as an antigenic molecule to induce immune responses from humans. Western blot analysis using anti-Tv alpha-actinin 2 anti-bodies indicated its presence in the secreted proteins of T. vaginalis. ELISA was employed to measure cytokine production by vaginal epithelial cells, prostate cells, mouse dendritic cells (DCs), or T cells stimulated with T. vaginalis or Tv alpha-actinin 2 protein. Both T. vaginalis and rTva-actinin 2 induced cytokine production from epithelial cell lines, including IL-10. Moreover, CD4(+)CD25(-) regulatory T cells (Treg cells) incubated with rTv alpha-actinin 2-treated DCs produced high levels of IL-10. These data indicate that Tv alpha-actinin 2 modulates immune responses via IL-10 production by Treg cells.
URI
http://parasitol.kr/journal/view.php?doi=10.3347/kjp.2017.55.4.375https://repository.hanyang.ac.kr/handle/20.500.11754/115100
ISSN
0023-4001; 1738-0006
DOI
10.3347/kjp.2017.55.4.375
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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