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Once-daily dosing of amikacin for treatment of Mycobacterium abscessus lung disease

Title
Once-daily dosing of amikacin for treatment of Mycobacterium abscessus lung disease
Author
이현
Keywords
non-tuberculous mycobacteria; M. abscessus; AMK; nephrotoxicity; ototoxicity
Issue Date
2017-07
Publisher
INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
Citation
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, v. 21, no. 7, page. 818-824
Abstract
SETTING: Tertiary referral centre, Samsung Medical Center, South Korea. OBJECTIVE: To evaluate the pharmacokinetic parameters and toxicities of once-daily amikacin (AMK) dosing for lung disease due to Mycobacterium abscessus. DESIGN: A retrospective review of 48 patients with M. abscessus lung disease who received once-daily AMK for 4 weeks between January 2012 and June 2015. RESULTS: With a starting dose of 15 mg/kg/day and adjustment of AMK dose according to the peak serum level (C-max), the C-max target of 55-65 mu g/ml was achieved in 31.3% (15/48) of patients in the first week, 68.8% (33/48) in week 2, 91.7% (44/48) in week 3 and 95.8% (46/48) in week 4. Transient nephrotoxicity developed in 6.3% (3/48) of patients and ototoxicity in 25.0% (6/24), which was determined by audiogram as hearing loss, asymptomatic in five patients and tinnitus in one. Multivariate analysis revealed that the highest drug concentration 12 h after administration was significantly associated with the development of toxicities (adjusted odds ratio 1.862, P = 0.047). CONCLUSION: Our results suggest that once-daily AMK for 4 weeks with a target C-max of 55-65 mu g/ml can be used in patients with M. abscessus lung disease, with careful monitoring of toxicity.
URI
https://www.ingentaconnect.com/content/iuatld/ijtld/2017/00000021/00000007/art00018https://repository.hanyang.ac.kr/handle/20.500.11754/115019
ISSN
1027-3719; 1815-7920
DOI
10.5588/ijtld.16.0791
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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