164 68

Incorporating Risk Factors to Identify the Indication of Post-Mastectomy Radiotherapy in N1 Breast Cancer Treated With Optimal Systemic Therapy: A Multicenter Analysis in Korea (KROG 14-23)

Title
Incorporating Risk Factors to Identify the Indication of Post-Mastectomy Radiotherapy in N1 Breast Cancer Treated With Optimal Systemic Therapy: A Multicenter Analysis in Korea (KROG 14-23)
Author
박혜진
Keywords
Breast neoplasms; Post-mastectomy radiotherapy; Risk factors
Issue Date
2017-07
Publisher
KOREAN CANCER ASSOCIATION
Citation
CANCER RESEARCH AND TREATMENT, v. 49, no. 3, page. 739-747
Abstract
Purpose In a recent meta-analysis, post-mastectomy radiotherapy (PMRT) reduced any first recurrence (AFR) and improved survival in N1 and N2 patients. We investigated risk factors for AFR in N1 after optimal systemic therapy without PMRT, to define a subgroup of patients who may benefit from PMRT. Materials and Methods One thousand three hundred eighty-two pT1-2N1M0 breast cancer patients treated with mastectomy without PMRT between 2005 and 2010 were retrospectively analyzed. Only 0.6% had no systemic therapy. Results After a median follow-up of 5.9 years, there were 173 AFR (53 loco-regional recurrence [LRR] without distant metastases [DM], 38 LRR with DM, and 82 DM without LRR). The 5-year LRR and AFR rates were 6.1% and 12.0%, respectively. Multivariate analysis revealed that close resection margin (p=0.001) was the only independent risk factor for LRR. Multivariate analysis for AFR revealed that age < 35 years (p=0.025), T2 stage (p=0.004), high tumor grade (p=0.032), close resection margin (p=0.035), and triple-negative biological subtype (p=0.031) were independent risk factors. Two or three positive lymph nodes (p=0.078) were considered a marginally significant factor. When stratified by these six factors, the 5-year LRR rates were 3.6% with 0-1 (n=606), 7.5% with 2-3 (n=655), and 12.7% with 4-6 (n=93) risk factors. The 5-year AFR rates were 7.1% with 0-1, 15.0% with 2-3, and 24.5% with 4-6 risk factors. Conclusion Patients with pT1-2N1M0 breast cancer who underwent mastectomy and optimal systemic therapy showed excellent loco-regional control and disease control. The patients with four or more risk factors may benefit from PMRT, and those with two or three risk factors merit consideration of PMRT.
URI
https://repository.hanyang.ac.kr/handle/20.500.11754/115017https://www.e-crt.org/journal/view.php?doi=10.4143/crt.2016.405
ISSN
1598-2998; 2005-9256
DOI
10.4143/crt.2016.405
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
Incorporating Risk Factors to Identify the Indication of Post-mastectomy Radiotherapy in N1 Breast Cancer Treated with Optimal Systemic Therapy ~.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE