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PI-RADS version 2: quantitative analysis aids reliable interpretation of diffusion-weighted imaging for prostate cancer

Title
PI-RADS version 2: quantitative analysis aids reliable interpretation of diffusion-weighted imaging for prostate cancer
Author
신수진
Keywords
PI-RADS; Diffusion-weighted imaging; Apparent diffusion coefficient; MRI; Prostate cancer
Issue Date
2017-07
Publisher
SPRINGER
Citation
EUROPEAN RADIOLOGY, v. 27, no. 7, page. 2776-2783
Abstract
To determine whether apparent diffusion coefficient (ADC) ratio aids reliable interpretation of diffusion-weighted imaging (DWI) for prostate cancer (PCa). Seventy-six consecutive patients with PCa who underwent DWI and surgery were included. Based on pathologic tumour location, two readers independently performed DWI scoring according to the revised Prostate Imaging Reporting and Data System (PI-RADSv2). ADC ratios of benign to cancerous prostatic tissue were then measured independently and compared between cases showing concordant and discordant DWI scores ae4. Area under the curve (AUC) and threshold of ADC ratio were analyzed for DWI scores ae4. The rate of inter-reader disagreement for DWI score ae4 was 11.8% (9/76). ADC ratios were higher in concordant vs. discordant DWI scores ae4 (median, 1.7 vs. 1.1-1.2; p < 0.001). For DWI scores ae4, the AUCs of ADC ratios were 0.970 for reader 1 and 0.959 for reader 2. In patients with an ADC ratio > 1.3, the rate of inter-reader disagreement for DWI score ae4 decreased to 5.9-6.0%. An ADC ratio > 1.3 yielded 100% (reader 1, 54/54; reader 2, 51/51) positive predictive value for clinically significant cancer. ADC ratios may be useful for reliable interpretation of DWI score ae4 in PI-RADSv2. aEuro cent The ADC ratio correlated positively with DWI score of PI-RADSv2. aEuro cent ADC ratio > 1.3 was associated with concordant interpretation of DWI score >= 4. aEuro cent ADC ratio > 1.3 was associated with high PPV for clinically significant cancer. aEuro cent ADC ratio is useful for reliable interpretation of DWI scoring in PI-RADSv2.
URI
https://link.springer.com/article/10.1007%2Fs00330-016-4678-7https://repository.hanyang.ac.kr/handle/20.500.11754/115006
ISSN
0938-7994; 1432-1084
DOI
10.1007/s00330-016-4678-7
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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