Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이동윤 | - |
dc.date.accessioned | 2019-11-27T20:22:03Z | - |
dc.date.available | 2019-11-27T20:22:03Z | - |
dc.date.issued | 2017-07 | - |
dc.identifier.citation | BIOMATERIALS, v. 133, page. 242-252 | en_US |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.issn | 1878-5905 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0142961217302521?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/114979 | - |
dc.description.abstract | Transplanted islets suffer hypoxic stress, which leads to nonspecific inflammation. This is the major cause of islet graft failure during the early stage of intrahepatic islet transplantation. Although bilirubin has shown potent anti-oxidative and anti-inflammatory functions, its clinical applications have been limited due to its insolubility and short half-life. To overcome this problem, novel amphiphilic bilirubin nanoparticles are designed. Hydrophilic poly(ethylene glycol) (PEG) is conjugated to the hydrophobic bilirubin molecule. Then, the PEG-bilirubin conjugates form nanoparticles via self-assembly, i.e., so-called to BRNPs. BRNPs can protect islet cells not only from chemically induced oxidative stress by scavenging reactive oxygen species molecules, but also from activated macrophages by suppressing cytokine release. Importantly, in vivo experiments demonstrate that BRNP treatment can dramatically and significantly prolong islet graft survival compared to bilirubin treatment. In addition, immunohistochemical analysis shows BRNPs have potent anti-oxidative and anti-inflammatory capabilities. Collectively, novel BRNPs can be a new potent remedy for successful islet transplantation. (C) 2017 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | This study was supported by a grant from the National Leading Research Laboratory (NRF-2015R1A2A1A05001832) and from Basic Science Research Program (NRF-2015M3A9E2030125) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning, Korea Government. The authors declare no competing financial interest. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCI LTD | en_US |
dc.subject | Pancreatic islet | en_US |
dc.subject | PEGylated bilirubin nanoparticles (BRNPs) | en_US |
dc.subject | Hypoxia | en_US |
dc.subject | Reactive oxygen species (ROS) | en_US |
dc.subject | Inflammation | en_US |
dc.title | PEGylated bilirubin nanoparticle as an anti-oxidative and anti- inflammatory demulcent in pancreatic islet xenotransplantation | en_US |
dc.type | Article | en_US |
dc.relation.volume | 133 | - |
dc.identifier.doi | 10.1016/j.biomaterials.2017.04.029 | - |
dc.relation.page | 242-252 | - |
dc.relation.journal | BIOMATERIALS | - |
dc.contributor.googleauthor | Kim, Min Jun | - |
dc.contributor.googleauthor | Lee, Yonghyun | - |
dc.contributor.googleauthor | Jon, Sangyong | - |
dc.contributor.googleauthor | Lee, Dong Yun | - |
dc.relation.code | 2017001471 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | dongyunlee | - |
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