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PEGylated bilirubin nanoparticle as an anti-oxidative and anti- inflammatory demulcent in pancreatic islet xenotransplantation

Title
PEGylated bilirubin nanoparticle as an anti-oxidative and anti- inflammatory demulcent in pancreatic islet xenotransplantation
Author
이동윤
Keywords
Pancreatic islet; PEGylated bilirubin nanoparticles (BRNPs); Hypoxia; Reactive oxygen species (ROS); Inflammation
Issue Date
2017-07
Publisher
ELSEVIER SCI LTD
Citation
BIOMATERIALS, v. 133, page. 242-252
Abstract
Transplanted islets suffer hypoxic stress, which leads to nonspecific inflammation. This is the major cause of islet graft failure during the early stage of intrahepatic islet transplantation. Although bilirubin has shown potent anti-oxidative and anti-inflammatory functions, its clinical applications have been limited due to its insolubility and short half-life. To overcome this problem, novel amphiphilic bilirubin nanoparticles are designed. Hydrophilic poly(ethylene glycol) (PEG) is conjugated to the hydrophobic bilirubin molecule. Then, the PEG-bilirubin conjugates form nanoparticles via self-assembly, i.e., so-called to BRNPs. BRNPs can protect islet cells not only from chemically induced oxidative stress by scavenging reactive oxygen species molecules, but also from activated macrophages by suppressing cytokine release. Importantly, in vivo experiments demonstrate that BRNP treatment can dramatically and significantly prolong islet graft survival compared to bilirubin treatment. In addition, immunohistochemical analysis shows BRNPs have potent anti-oxidative and anti-inflammatory capabilities. Collectively, novel BRNPs can be a new potent remedy for successful islet transplantation. (C) 2017 Elsevier Ltd. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0142961217302521?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/114979
ISSN
0142-9612; 1878-5905
DOI
10.1016/j.biomaterials.2017.04.029
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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