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dc.contributor.author이종민-
dc.date.accessioned2019-11-27T19:39:43Z-
dc.date.available2019-11-27T19:39:43Z-
dc.date.issued2017-07-
dc.identifier.citationEUROPEAN JOURNAL OF NEUROLOGY, v. 24, no. 7, page. 966-973en_US
dc.identifier.issn1351-5101-
dc.identifier.issn1468-1331-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/ene.13321-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/114956-
dc.description.abstractBackground and purpose: The occult changes in normal-appearing white matter (NAWM) were investigated and compared amongst patients with neuromyelitis optica spectrum disorder (NMOSD), patients with multiple sclerosis (MS) and healthy controls (HCs) by applying tract-based spatial statistics to diffusion tensor imaging (DTI) data. Methods: Diffusion tensor imaging was performed with a 3-T scanner in 93 patients with NMOSD, 53 patients with MS and 43 HCs. Voxel-wise statistical analyses of the DTI data were performed using tract-based spatial statistics. Results: Compared to HCs, patients with NMOSD had significantly lower mean global fractional anisotropy, higher mean diffusivity and radial diffusivity, and no significant differences in axial diffusivity in their NAWM. Patients with MS demonstrated significantly lower mean global fractional anisotropy and higher mean diffusivity, axial diffusivity and radial diffusivity in the NAWM than did patients with NMOSD and HCs. Compared to patients with NMOSD, patients with MS had NAWM damage that was more extensive, particularly in the inferior cerebellar peduncle, external capsule, cingulum, superior fronto-occipital fasciculus and uncinate fasciculus. Conclusions: Using DTI, widespread occult damage was demonstrated in the NAWM of patients with NMOSD. However, the NAWM was less affected in patients with NMOSD than it was in patients with MS; specifically, the axonal injuries and diffusion abnormalities in the association fibers were more severe in patients with MS than they were in patients with NMOSD.en_US
dc.description.sponsorshipThis work was funded by the National Research Foundation of Korea (Grant No. 2013R1A1A2058612) and the Brain Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (NRF-2014M3C7A1046050).en_US
dc.language.isoen_USen_US
dc.publisherWILEYen_US
dc.subjectdiffusion tensor imagingen_US
dc.subjectmultiple sclerosisen_US
dc.subjectneuromyelitis opticaen_US
dc.titleDiffusion tensor imaging of normal-appearing white matter in patients with neuromyelitis optica spectrum disorder and multiple sclerosisen_US
dc.typeArticleen_US
dc.relation.no7-
dc.relation.volume24-
dc.identifier.doi10.1111/ene.13321-
dc.relation.page966-973-
dc.relation.journalEUROPEAN JOURNAL OF NEUROLOGY-
dc.contributor.googleauthorKim, S. -H.-
dc.contributor.googleauthorKwak, K.-
dc.contributor.googleauthorHyun, J. -W.-
dc.contributor.googleauthorJoung, A.-
dc.contributor.googleauthorLee, S. H.-
dc.contributor.googleauthorChoi, Y. -H.-
dc.contributor.googleauthorLee, J. -M.-
dc.contributor.googleauthorKim, H. J.-
dc.relation.code2017011613-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING-
dc.identifier.pidljm-
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COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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