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CT-P13 in the treatment of rheumatoid arthritis

Title
CT-P13 in the treatment of rheumatoid arthritis
Author
유대현
Keywords
Rheumatoid arthritis; treatment; infliximab; biosimilar; CT-P13
Issue Date
2017-07
Publisher
TAYLOR & FRANCIS LTD
Citation
EXPERT REVIEW OF CLINICAL IMMUNOLOGY, v. 13, no. 7, page. 653-666
Abstract
Introduction: The first biosimilar infliximab, CT-P13 infliximab-dyyb was approved in 2013 by the European Medicines Agency (EMA) and in 2016 by the United States Food and Drug Administration (FDA) and has been used for the treatment of rheumatoid arthritis (RA) for 4years.Areas covered: CT-P13 with the three brand names on the market has highly similar efficacy and safety profiles but lower price than originator infliximab and are approved in more than 80 countries. One of the most important determinants of the implementation of CT-P13 in the treatment of RA is scientific evidence from clinical studies and real-world pharmacovigilance data. Here, we review all available clinical data supporting the similarity of CT-P13 to originator infliximab in its clinical efficacy and safety for the treatment of RA and related arthritis. In addition, we consider the role of CT-P13 in therapeutic strategies for RA treatment.Expert commentary: With its highly similar efficacy and safety profile to originator infliximab and its lower price, CT-P13 is expected to be very useful in RA treatment, whether it is applied earlier or switched from originator infliximab or other biologics. Future educational initiatives will be important to overcome misunderstandings about biosimilars and to improve the implementation of CT-P13.
URI
https://www.tandfonline.com/doi/abs/10.1080/1744666X.2017.1337510?journalCode=ierm20https://repository.hanyang.ac.kr/handle/20.500.11754/114924
ISSN
1744-666X; 1744-8409
DOI
10.1080/1744666X.2017.1337510
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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