Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김승현 | - |
dc.date.accessioned | 2019-11-26T21:14:40Z | - |
dc.date.available | 2019-11-26T21:14:40Z | - |
dc.date.issued | 2017-07 | - |
dc.identifier.citation | JOURNAL OF CLINICAL NEUROLOGY, v. 13, no. 3, page. 234-242 | en_US |
dc.identifier.issn | 1738-6586 | - |
dc.identifier.issn | 2005-5013 | - |
dc.identifier.uri | https://thejcn.com/DOIx.php?id=10.3988/jcn.2017.13.3.234 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/114857 | - |
dc.description.abstract | Background and Purpose Only a few studies have investigated the relationship between different subtypes and disease progression or prognosis in patients with behavioral variant frontotemporal dementia (bvFTD). Since a localized injury often produces more focal signs than a diffuse injury, we hypothesized that the clinical characteristics differ between patients with bvFTD who show diffuse frontal lobe atrophy (D-type) on axial magnetic resonance imaging (MRI) scans versus those with focal or circumscribed frontal lobe atrophy(F-type). Methods In total, 94 MRI scans (74 scans from bvFTD and 20 scans from age-matched normal controls) were classified into 35 D- and 39 F-type bvFTD cases based on an axial MRI visual rating scale. We compared baseline clinical characteristics, progression in motor and cognitive symptoms, and survival times between D-and F-types. Survival analyses were performed for 62 of the 74 patients. Results While D-type performed better on neuropsychological tests than F-type at baseline, D-type had higher baseline scores on the Unified Parkinson's Disease Rating Scale (UPDRS) Part III. Evaluations of motor progression showed that the disease duration with motor symptoms was shorter in D-type than F-type. Moreover, the survival time was shorter in D-type (6.9 years) than F-type (9.4 years). Cox regression analyses revealed that a high UPDRS Part III score at baseline contributed to an increased risk of mortality, regardless of the pattern of atrophy. Conclusions The prognosis is worse for D-type than for those with F-type. Shorter survival in D-type maybe associated with the earlier appearance of motor symptoms. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health, Welfare and Family Affairs, Republic of Korea (HI12C0135, HI10C2020, and HI14C2746). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN NEUROLOGICAL ASSOC | en_US |
dc.subject | frontotemporal dementia | en_US |
dc.subject | frontotemporal lobar degeneration | en_US |
dc.subject | magnetic resonance imaging | en_US |
dc.subject | prognosis | en_US |
dc.title | Prognosis of Patients with Behavioral Variant Frontotemporal Dementia Who have Focal Versus Diffuse Frontal Atrophy | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 13 | - |
dc.identifier.doi | 10.3988/jcn.2017.13.3.234 | - |
dc.relation.page | 234-242 | - |
dc.relation.journal | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.contributor.googleauthor | Lee, Jin San | - |
dc.contributor.googleauthor | Jung, Na-Yeon | - |
dc.contributor.googleauthor | Jang, Young Kyoung | - |
dc.contributor.googleauthor | Kim, Hee Jin | - |
dc.contributor.googleauthor | Seo, Sang Won | - |
dc.contributor.googleauthor | Lee, Juyoun | - |
dc.contributor.googleauthor | Kim, Yeo Jin | - |
dc.contributor.googleauthor | Lee, Jae-Hong | - |
dc.contributor.googleauthor | Kim, Byeong C. | - |
dc.contributor.googleauthor | Kim, Seung Hyun | - |
dc.relation.code | 2017010495 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kimsh1 | - |
dc.identifier.researcherID | T-5133-2017 | - |
dc.identifier.orcid | http://orcid.org/0000-0001-9644-9598 | - |
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