117 44

Clinical features and outcomes of patients with hepatocellular carcinoma complicated with bile duct invasion

Title
Clinical features and outcomes of patients with hepatocellular carcinoma complicated with bile duct invasion
Author
안지현
Keywords
Hepatocellular carcinoma; Bile duct invasion; Treatment; Prognosis; Obstructive jaundice
Issue Date
2017-06
Publisher
KOREAN ASSOC STUDY LIVER
Citation
CLINICAL AND MOLECULAR HEPATOLOGY, v. 23, no. 2, page. 160-169
Abstract
Background/Aims: Little is known about the treatment or outcomes of hepatocellular carcinoma (HCC) complicated with bile duct invasion.Methods: A total of 247 consecutive HCC patients with bile duct invasion at initial diagnosis were retrospectively included.Results: The majority of patients had Barcelona Clinic Liver Cancer (BCLC) stage C HCC (66.8%). Portal vein tumor thrombosis was present in 166 (67.2%) patients. Median survival was 4.1 months. Various modalities of treatment were initially employed including surgical resection (10.9%), repeated transarterial chemoembolization (TACE) (42.5%), and conservative management (42.9%). Among the patients with obstructive jaundice (n=88), successful biliary drainage was associated with better overall survival rate. Among the patients with BCLC stage C, overall survival differed depending on the initial treatment for HCC; surgical resection, TACE, systemic chemotherapy, and conservative management showed overall survival rates of 11.5, 6.0,2.4, and 1.6 months, respectively. After adjusting for confounders, surgical resection and repeated TACE were significant prognostic factors for HCC patients with bile duct invasion (hazard ratios 0.47 and 0.39, Ps < 0.001, respectively).Conclusions: The survival of HCC patients with bile duct invasion at initial diagnosis is generally poor. However, aggressive treatments for HCC such as resection or biliary drainage may be beneficial therapeutic options for patients with preserved liver function.
URI
https://www.e-cmh.org/journal/view.php?doi=10.3350/cmh.2016.0088https://repository.hanyang.ac.kr/handle/20.500.11754/114697
ISSN
2287-2728; 2287-285X
DOI
10.3350/cmh.2016.0088
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
Clinical features and outcomes of patients with hepatocellular carcinoma complicated with bile duct invasion.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE