Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2019-11-26T05:59:15Z | - |
dc.date.available | 2019-11-26T05:59:15Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.citation | CANCER LETTERS, v. 396, page. 155-166 | en_US |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.issn | 1872-7980 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0304383517301738?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/114639 | - |
dc.description.abstract | Pancreatic cancer is a highly lethal disease for which limited therapeutic options are available. Pancreatic cancer exhibits a pronounced collagen-rich stromal reaction, which induces chemoresistance by inhibiting drug diffusion into the tumor. Complementary treatment with oncolytic virus such as an oncolytic adenovirus expressing relaxin (YDC002) is an innovative treatment option for combating chemoresistant pancreatic cancer. Here, we examined the ability of combined treatment with gemcitabine and YDC002, which degrades extracellular matrix (ECM), to efficiently treat chemoresistant and desmoplastic pancreatic cancer. Gemcitabine alone exhibited similarly low cytotoxicity toward pancreatic cancer cells throughout the concentration range (1-50 mu M) used, whereas the combination of YDC002 and a sub therapeutic dose of gemcitabine (0.01-0.05 mu M) resulted in potent anticancer effects through effective induction of apoptosis. Importantly, YDC002 combined with gemcitabine significantly attenuated the expression of major ECM components including collagens, fibronectin, and elastin in tumor spheroids and xenograft tumors compared with gemcitabine alone, resulting in potent induction of apoptosis, gemcitabine-mediated cytotoxicity, and an oncolytic effect through degradation of tumor ECM. Our results demonstrate that YDC002 can selectively degrade aberrant ECM and attenuate the ECM-induced chemoresistance observed in desmoplastic pancreatic tumor, resulting in a potent antitumor effect through effective induction of apoptosis. (C) 2017 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This research was supported by grants from the National Research Foundation (NRF) of Korea (2015R1A2A1A10054108, 2015M3A9C407581, 2014M3C1A3051476 to S.S. Hong; 2015R1A2A1A13027811, 2016M3A9B5942352 to C.O. Yun), and a grant (HI15C0554) from the Korea Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER IRELAND LTD | en_US |
dc.subject | Adenovirus | en_US |
dc.subject | Relaxin | en_US |
dc.subject | Gemcitabine | en_US |
dc.subject | Extracellular matrix | en_US |
dc.subject | Pancreatic cancer | en_US |
dc.title | Oncolytic adenovirus expressing relaxin (YDC002) enhances therapeutic efficacy of gemcitabine against pancreatic cancer | en_US |
dc.type | Article | en_US |
dc.relation.no | 396 | - |
dc.relation.volume | 28 | - |
dc.identifier.doi | 10.1016/j.canlet.2017.03.009 | - |
dc.relation.page | 155-166 | - |
dc.relation.journal | CANCER LETTERS | - |
dc.contributor.googleauthor | Jung, Kyung Hee | - |
dc.contributor.googleauthor | Choi, Il-Kyu | - |
dc.contributor.googleauthor | Lee, Hee-Seung | - |
dc.contributor.googleauthor | Yan, Hong Hua | - |
dc.contributor.googleauthor | Son, Mi Kwon | - |
dc.contributor.googleauthor | Ahn, Hyo Min | - |
dc.contributor.googleauthor | Hong, JinWoo | - |
dc.contributor.googleauthor | Yun, Chae-Ok | - |
dc.contributor.googleauthor | Hong, Soon-Sun | - |
dc.relation.code | 2017001067 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | chaeok | - |
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