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돌발성 난청에서 스테로이드 투여 방법에 따른 치료 결과의 차이

Title
돌발성 난청에서 스테로이드 투여 방법에 따른 치료 결과의 차이
Other Titles
The Comparison of Treatment Outcomes between IV and Oral Steroid in Sudden Sensorineural Hearing Loss ; Propensity Score Matching Analysis
Author
이승환
Keywords
돌발성난청; 스테로이드; Sudden sensorineural hearing loss; Steroid
Issue Date
2017-06
Publisher
대한이비인후과학회 부산,울산,경남 지부회
Citation
임상이비인후과, v. 28, no. 1, page. 42-48
Abstract
The aims of the study was to compare the treatment outcomes associated with the steroid administration routes in unilateral sudden sensorineural hearing loss. Methods:From January 1998 to December 2014, three hundred and eighteen patients with unilateral sudden sensorineural hearing loss were assessed. Among them, 34 patients received the intravenous dexamethasone (16 mg/day)while the others 284 patients received 1mg/kg prednisolone daily with a subsequently tapered dose. We performed a propensity score matching analysis using previously known prognostic factors including initial hearing level, presence of vertigo and duration of onset of treatment to compare treatment outcome of IV and oral steroid. The hearing recovery between the IV steroid group and propensity score matched oral steroid group was assessed according to the AAO-HNS guideline and Siegel’s criteria. Results:In the comparison between oral and IV steroid group, mean age, the initial hearing level was significantly higher in the oral steroid group than in IV steroid group (p=0.002, p=0.003) After propensity score matching, initial hearing level, age, sex and other clinical parameters were not significantly different between IV steroid and matched oral steroid group. In the treatment outcome, the complete recovery rate in IV steroid and the oral steroid group were 64.7% and 47.1% respectively. Although the recovery rate of the IV steroid group was higher than that of the oral steroid group, statistical significance was not identified. Conclusions:The administration route of systemic steroid did not affect the clinical outcomes of idiopathic sudden sensorineural hearing loss.
URI
https://www.kci.go.kr/kciportal/landing/article.kci?arti_id=ART002241136https://repository.hanyang.ac.kr/handle/20.500.11754/114566
ISSN
1225-0244
DOI
10.35420/jcohns.2017.28.1.42
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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