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dc.contributor.author주재범-
dc.date.accessioned2019-11-26T05:00:52Z-
dc.date.available2019-11-26T05:00:52Z-
dc.date.issued2017-06-
dc.identifier.citationACS NANO, v. 11, no. 5, page. 4926-4933en_US
dc.identifier.issn1936-0851-
dc.identifier.issn1936-086X-
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acsnano.7b01536-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/114556-
dc.description.abstractAccurate analysis of specific biomarkers in clinical serum is essential for early diagnosis and treatment of cancer. Here, a surface-enhanced Raman scattering (SERS)-based immunoassay, using magnetic beads and SERS nano tags, was developed for the determination of free to total (f/t) prostate specific antigen (PSA) ratio to improve the diagnostic performance of prostate cancer. To assess the clinical applicability of the proposed method, SERS-based assays for the simultaneous detection of dual PSA markers, free PSA (f-PSA) and complexed PSA (c-PSA), were performed for clinical samples in the gray zone between 4.0 and 10.0 ng/mL. Our assay results for f/t PSA ratio showed a good linear correlation with those measured using the electrochemiluminescence (ECL) system installed in the clinical laboratory of the University Hospital. In addition, the simultaneous assay provided better precision than parallel assays for the detection of f-PSA and c-PSA in 13 clinical serum samples. Therefore, our SERS-based assay for simultaneous detection of dual PSA markers in clinical fluids has strong potential for application in the accurate diagnosis of prostate cancer.en_US
dc.description.sponsorshipThe National Research Foundation of Korea supported this work through grant numbers R11-2008-0061852 and K20904000004-12A0500-00410. The Nano Material Technology Development Program also supported this work, through the National Research Foundation of Korea, funded by the Ministry of Education, Science, and Technology (grant number 2012035286). This work was also partially supported by the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health and Welfare, Korea (HI16C2129). L.C. thanks the National Natural Science Foundation of China (21575159) for financial support.en_US
dc.language.isoen_USen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.subjectSERS-based immunoassayen_US
dc.subjectmultiplex detectionen_US
dc.subjectprostate canceren_US
dc.subjectfree to total PSA ratioen_US
dc.subjectsimultaneous detectionen_US
dc.titleSimultaneous Detection of Dual Prostate Specific Antigens Using Surface-Enhanced Raman Scattering-Based Immunoassay for Accurate Diagnosis of Prostate Canceren_US
dc.typeArticleen_US
dc.relation.no5-
dc.relation.volume11-
dc.identifier.doi10.1021/acsnano.7b01536-
dc.relation.page4926-4933-
dc.relation.journalACS NANO-
dc.contributor.googleauthorCheng, Ziyi-
dc.contributor.googleauthorChoi, Namhyun-
dc.contributor.googleauthorWang, Rui-
dc.contributor.googleauthorLee, Sangyeop-
dc.contributor.googleauthorMoon, Kyung Chul-
dc.contributor.googleauthorYoon, Soo-Young-
dc.contributor.googleauthorChen, Lingxin-
dc.contributor.googleauthorChoo, Jaebum-
dc.relation.code2017000564-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidjbchoo-
dc.identifier.orcidhttp://orcid.org/0000-0003-3864-6459-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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