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Efficacy and safety of evogliptin monotherapy in patients with type 2 diabetes and moderately elevated glycated haemoglobin levels after diet and exercise

Title
Efficacy and safety of evogliptin monotherapy in patients with type 2 diabetes and moderately elevated glycated haemoglobin levels after diet and exercise
Author
이창범
Keywords
antidiabetic drug; clinical trial; DPP-4 inhibitor; phase III study; type 2 diabetes
Issue Date
2017-06
Publisher
WILEY
Citation
DIABETES OBESITY & METABOLISM, v. 19, no. 12, page. 1681-1687
Abstract
Aims: To evaluate the efficacy and safety of evogliptin, a newly developed dipeptidyl peptidase-4 inhibitor, in patients with type 2 diabetes (T2D) inadequately controlled by diet and exercise.Materials and Methods: In this randomized, double-blind, placebo-controlled, parallel-group, multicentre, phase III study, 160 patients with T2D were assigned to either evogliptin 5 mg or placebo for 24 weeks. The primary endpoint was the mean change in glycated haemoglobin (HbA1c) from baseline to week 24.Results: The mean baseline HbA1c levels were similar in the evogliptin and the placebo groups (7.20% 0.56% vs 7.20% +/- 0.63%, respectively). At week 24, evogliptin significantly reduced HbA1c levels from baseline compared with placebo (-0.23% vs 0.05%, respectively, P < .0001). Additionally, the proportion of patients achieving HbA1c <6.5% was significantly higher in the evogliptin group than in the placebo group (33.3% vs 15.2%; P = .008). The overall incidence of adverse events, including hypoglycaemia, was similar in the 2 groups.Conclusions: In this 24-week study, once-daily evogliptin monotherapy significantly improved glycaemic control and was well tolerated in patients with T2D.
URI
https://onlinelibrary.wiley.com/doi/full/10.1111/dom.12987https://repository.hanyang.ac.kr/handle/20.500.11754/114554
ISSN
1462-8902; 1463-1326
DOI
10.1111/dom.12987
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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