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Calprotectin levels in rheumatoid arthritis and their correlation with disease activity: a meta-analysis

Title
Calprotectin levels in rheumatoid arthritis and their correlation with disease activity: a meta-analysis
Author
배상철
Keywords
Calprotectin; rheumatoid arthritis; activity
Issue Date
2017-06
Publisher
TAYLOR & FRANCIS LTD
Citation
POSTGRADUATE MEDICINE, v. 129, no. 5, page. 531-537
Abstract
Objective: We evaluated the relationship between calprotectin levels and rheumatoid arthritis (RA), and the correlation between plasma/serum calprotectin and RA activity.Methods: We searched PUBMED, EMBASE, and Cochrane databases and performed meta-analyses comparing plasma/serum or synovial fluid calprotectin levels in RA patients and controls, and correlation coefficients between calprotectin levels and disease activity for 28 joints (DAS28) as well as C-reactive protein (CRP) in RA patients.Results: Sixteen studies including 849 RA patients and 266 controls were available for meta-analysis. Meta-analysis showed that calprotectin levels were significantly higher in the RA group than in the control group (SMD = 2.337, 95% CI = 1.544-3.130, p < 1.0x10(-8)). Stratification by rheumatoid factor (RF) status revealed significantly elevated calprotectin levels in the RF-positive RA group compared to that of the RF-negative RA group (SMD = 0.574, 95% CI = 0.345-0.804, p = 9.2x10(-7)). Meta-analysis of correlation coefficients identified a significant positive correlation between calprotectin levels and CRP or DAS28 (correlation coefficient for CRP = 0.566, 95% CI = 0.512-0.615, p < 1.0x10(-8); correlation coefficient for DAS28 = 0.438, 95% CI = 0.269-0.518, p = 2.5x10(-6)). Calprotectin levels in synovial fluid were significantly higher in the RA group than in the control group (SMD = 2.891, 95% CI = 1.067-4.715, p = 0.002).Conclusions: Our meta-analysis demonstrates that circulating and synovial fluid calprotectin levels are high in patients with RA, and that circulating calprotectin levels positively correlate with RA activity.
URI
https://www.tandfonline.com/doi/full/10.1080/00325481.2017.1319729https://repository.hanyang.ac.kr/handle/20.500.11754/114540
ISSN
0032-5481; 1941-9260
DOI
10.1080/00325481.2017.1319729
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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