77 0

Clinical Investigation Into Plasma Neutrophil Gelatinase-Associated Lipocalin and Body Adipose Tissue Associated With Remaining Renal Function in Living Kidney Donor.

Title
Clinical Investigation Into Plasma Neutrophil Gelatinase-Associated Lipocalin and Body Adipose Tissue Associated With Remaining Renal Function in Living Kidney Donor.
Author
윤영은
Keywords
POOLED ANALYSIS; CELL CARCINOMA; NEPHRECTOMY; DISEASE; INJURY; INFLAMMATION; TRANSPLANT; MORTALITY; BIOMARKER; SURGERY
Issue Date
2017-06
Publisher
ELSEVIER SCIENCE INC
Citation
TRANSPLANTATION PROCEEDINGS, v. 49, no. 5, page. 935-939
Abstract
Objective. Plasma neutrophil gelatinase-associated lipocalin (pNGAL) is known to increase in proportion to the degree and period of renal damage. This study aimed to evaluate the clinical relevance of pNGAL and body adipose tissue to remaining renal function in living kidney donors.Methods. Between July 2013 and February 2015, 75 live kidney donors were enrolled. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and VAT/SAT ratio were measured in preoperative CT scan which performed before surgery. We analyzed the correlation among the variables (VAT, SAT, and VAT/SAT ratio), eGFR and pNGAL. Delta pNGAL-max(=Maximum pNGAL-measures), Delta pNGAL-min(=Minimum pNGAL-measures), Delta eGFR-max(=Maximum eGFR-measures) and Delta eGFR-min(=Minimum eGFR-measures) were also analyzed.Results. The highest value of pNGAL (207.46 +/- 76 ng/mL) was observed on postoperative day 7, and the lowest value of eGFR (57.52 +/- 11.20 mL/min/1.73 m(2)) was also measured on postoperative day 7. A significant correlation was found between Delta pNGAL, VAT, and VAT-to-SAT ratio. Moreover, a significant correlation between Delta pNGALmin and Delta eGFRmin was revealed. Also, VAT-to-SAT ratio was correlated with Delta eGFRmin during the all of the follow-up periods, and it was also correlated with Delta pNGALmin until postoperative day 3.Conclusion. There was a correlation between the elevation of pNGAL until postoperative day 5 and the decrease of eGFR after living donor nephrectomy. VAT-to-SAT ratio had a significant correlation with both Delta pNGALmin and eGFRmin. Given the metabolism of pNGAL, the increase of pNGAL seemed to be affected as a consequence of body adipose tissue.
URI
https://www.sciencedirect.com/science/article/abs/pii/S0041134517302580?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/114526
ISSN
0041-1345; 1873-2623
DOI
10.1016/j.transproceed.2017.03.041
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE