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Deubiquitylation of deubiquitylases

Title
Deubiquitylation of deubiquitylases
Author
Ramakrishna Suresh
Keywords
auto-regulation; deubiquitylating DUBs; proteasome degradation; self-deubiquitylation; ubiquitylation
Issue Date
2017-06
Publisher
ROYAL SOC
Citation
OPEN BIOLOGY, v. 7, no. 6, Article no. 170016
Abstract
Deubiquitylating enzymes (DUBs) reverse the ubiquitylation of target proteins, thereby regulating diverse cellular functions. In contrast to the plethora of research being conducted on the ability of DUBs to counter the degradation of cellular proteins or auto-ubiquitylated E3 ligases, very little is known about the mechanisms of DUB regulation. In this review paper, we summarize a novel possible mechanism of DUB deubiquitylation by other DUBs. The available data suggest the need for further experiments to validate and characterize this notion of 'Dubbing DUBs'. The current studies indicate that the idea of deubiquitylation of DUBs by other DUBs is still in its infancy. Nevertheless, future research holds the promise of validation of this concept.
URI
https://royalsocietypublishing.org/doi/10.1098/rsob.170016https://repository.hanyang.ac.kr/handle/20.500.11754/114507
ISSN
2046-2441
DOI
10.1098/rsob.170016
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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