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dc.contributor.author정지은-
dc.date.accessioned2019-11-26T02:38:42Z-
dc.date.available2019-11-26T02:38:42Z-
dc.date.issued2019-03-
dc.identifier.citationDRUG DESIGN DEVELOPMENT AND THERAPY, v. 13, Page. 1717-1727en_US
dc.identifier.issn1177-8881-
dc.identifier.urihttps://www.dovepress.com/genetic-variations-in-the-transcription-factors-gata4-and-gata6-and-bl-peer-reviewed-article-DDDT-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/114492-
dc.description.abstractPurpose: GATA4 and GATA6 are known to have potential roles in vascular regulation by affecting vascular smooth muscle cell differentiation and atrial natriuretic peptide levels. The aim of this retrospective study was to investigate the associations between GATA4 and GATA6 polymorphisms and bleeding complication risk at a therapeutic international normalized ratio (INR) in patients with mechanical heart valves. Patients and methods: Study patients were included from the Ewha-Severance Treatment (EAST) Group of Warfarin. It consisted of 229 patients who received warfarin therapy after undergoing mechanical heart valve replacement and maintained a stable INR (INR of 2.0-3.0 for at least three consecutive times). Twenty single-nucleotide polymorphisms including VKORC1, CYP2C9, GATA4, and GATA6 were analyzed. Multivariate logistic regression analysis was employed to investigate the independent risk factors for bleeding complications. To evaluate the potential clinical value of genotyping for preventing bleeding complications in patients with high-risk genotype, the number needed to genotype (NNG) was also calculated. Results: One hundred forty-two patients were included in this study, 21 of whom had bleeding complications. After adjusting covariates, TT genotype carriers of rs13273672 in GATA4 and CC genotype carriers of rs10454095 in GATA6 showed 5.0- (95% CI, 1.6-15.7) and 3.1-fold (95% CI, 1.1-8.7) higher bleeding complications than carriers of C allele and T allele, respectively. NNG for preventing one patient from experiencing bleeding complications in patients with TT genotype of rs13273672 and CC genotype of rs10454095 was 22.2 and 17.5, respectively. Patients with both TT genotype in rs13273672 and CC genotype in rs10454095 showed 8.7-fold (95% CI, 1.7-46.1) higher bleeding complications than those with other genotypes. NNG in patients having both TT genotype in rs13273672 and CC genotype in rs10454095 was calculated to be 40.0. Conclusions: This study showed that GATA4 and GATA6 gene polymorphisms could affect bleeding complications during warfarin treatment in patients with mechanical heart valves.en_US
dc.description.sponsorshipThis study was supported by Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education (No. 2017R1D1A1B03034033) and the research grant of the Chungbuk National University in 2014.en_US
dc.language.isoen_USen_US
dc.publisherDOVE MEDICAL PRESS LTDen_US
dc.subjectGATA4en_US
dc.subjectGATA6en_US
dc.subjectwarfarinen_US
dc.subjectbleedingen_US
dc.subjectpolymorphismen_US
dc.titleGenetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapyen_US
dc.typeArticleen_US
dc.relation.volume13-
dc.identifier.doi10.2147/DDDT.S198018-
dc.relation.page1717-1727-
dc.relation.journalDRUG DESIGN DEVELOPMENT AND THERAPY-
dc.contributor.googleauthorYee, J-
dc.contributor.googleauthorKim, W-
dc.contributor.googleauthorChang, BC-
dc.contributor.googleauthorChung, JE-
dc.contributor.googleauthorLee, KE-
dc.contributor.googleauthorGwak, H.S-
dc.relation.code2019037670-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidjechung-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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