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dc.contributor.authorKlaus Heese-
dc.date.accessioned2019-11-26T02:02:11Z-
dc.date.available2019-11-26T02:02:11Z-
dc.date.issued2017-06-
dc.identifier.citationMOLECULAR NEUROBIOLOGY, v. 54, no. 9, page. 7401-7459en_US
dc.identifier.issn0893-7648-
dc.identifier.issn1559-1182-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs12035-016-0214-7-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/114447-
dc.description.abstractNeurotrophins (NTs) are members of a neuronal growth factor protein family whose action is mediated by the tropomyosin receptor kinase (TRK) receptor family receptors and the p75 NT receptor (p75NTR), a member of the tumor necrosis factor (TNF) receptor family. Although NTs were first discovered in neurons, recent studies have suggested that NTs and their receptors are expressed in various types of stem cells mediating pivotal signaling events in stem cell biology. The concept of stem cell therapy has already attracted much attention as a potential strategy for the treatment of neurodegenerative diseases (NDs). Strikingly, NTs, proNTs, and their receptors are gaining interest as key regulators of stem cells differentiation, survival, self-renewal, plasticity, and migration. In this review, we elaborate the recent progress in understanding of NTs and their action on various stem cells. First, we provide current knowledge of NTs, proNTs, and their receptor isoforms and signaling pathways. Subsequently, we describe recent advances in the understanding of NT activities in various stem cells and their role in NDs, particularly Alzheimer's disease (AD) and Parkinson's disease (PD). Finally, we compile the implications of NTs and stem cells from a clinical perspective and discuss the challenges with regard to transplantation therapy for treatment of AD and PD.en_US
dc.description.sponsorshipThis study was supported by Hanyang University and by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2013R1A1A2009178).en_US
dc.language.isoen_USen_US
dc.publisherSPRINGERen_US
dc.subjectNeurotrophinen_US
dc.subjectBDNFen_US
dc.subjectNGFen_US
dc.subjectTRKen_US
dc.subjectStem cellen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectParkinson's diseaseen_US
dc.titleNeurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapyen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s12035-016-0214-7-
dc.relation.page1-59-
dc.relation.journalMOLECULAR NEUROBIOLOGY-
dc.contributor.googleauthorPramanik, Subrata-
dc.contributor.googleauthorSulistio, Yanuar Alan-
dc.contributor.googleauthorHeese, Klaus-
dc.relation.code2017000168-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S]-
dc.identifier.pidklaus-
dc.identifier.researcherIDM-8325-2019-
dc.identifier.orcidhttp://orcid.org/0000-0002-0027-6993-
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GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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