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dc.contributor.author신흥수-
dc.date.accessioned2019-11-26T01:55:26Z-
dc.date.available2019-11-26T01:55:26Z-
dc.date.issued2017-06-
dc.identifier.citationBIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v. 22, no. 2, page. 200-209en_US
dc.identifier.issn1226-8372-
dc.identifier.issn1976-3816-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs12257-016-0609-3-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/114439-
dc.description.abstractBioengineered skin substitute offers new opportunities for treating various skin ailments. To compensate the structural integrity problems of scaffolds prepared from natural components, we mechanically developed highly modified electrospun nanofibrous membranes, incorporating poly(l-lactide-co-epsilon-caprolactone) (PLCL) into gelatin [poly(l-lactide-co-epsilon-caprolactone)/ gelatin membrane, (P/G (3/7)]. Subsequent to our previous in vitro study, our goal was to evaluate the in vivo performance of PLCL, gelatin, and P/G (3/7) membranes, and investigate the feasibility of the newly developed P/G (3/7) membrane for wound healing. Histological analysis using the mathematical model of wound healing and contraction, revealed the association between stiffness of skin substitute with cytokeratin production and wound contraction rate, and the defect site covered with the stiffer membrane showed lower cytokeratin production, and inversely, higher wound contraction rate. Overall, the P/G (3/7) membrane induced a satisfactory wound healing outcome. However, lower cytokeratin production rate with the mechanically modified P/G membrane involves the importance of the conditional blending of PLCL. Conversely, the condition of PLCL showed some incompatibility and hindrance of skin regeneration, consistent with previous in vitro results. With proper mechanical strength and cell viability, the P/G (3/7) membrane could successfully be used as a suitable skin substitute scaffold.en_US
dc.description.sponsorshipThis research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI14C2143).en_US
dc.language.isoen_USen_US
dc.publisherKOREAN SOC BIOTECHNOLOGY & BIOENGINEERINGen_US
dc.subjectpoly(L-lactide-co-epsilon-caprolactone)en_US
dc.subjectgelatinen_US
dc.subjectwound healingen_US
dc.subjectskin substitutesen_US
dc.subjectmechanotransductionen_US
dc.titleEfficacy of mechanically modified electrospun poly(l-lactide-co-epsilon-caprolactone)/gelatin membrane on full-thickness wound healing in ratsen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume22-
dc.identifier.doi10.1007/s12257-016-0609-3-
dc.relation.page200-209-
dc.relation.journalBIOTECHNOLOGY AND BIOPROCESS ENGINEERING-
dc.contributor.googleauthorJeong, Sung-In-
dc.contributor.googleauthorKang, Yu-Jeoung-
dc.contributor.googleauthorLee, Kang-Sik-
dc.contributor.googleauthorShin, Heungsoo-
dc.contributor.googleauthorLee, Bu-Kyu-
dc.relation.code2017007320-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF BIOENGINEERING-
dc.identifier.pidhshin-
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COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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