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dc.contributor.author황승용-
dc.date.accessioned2019-11-26T01:35:03Z-
dc.date.available2019-11-26T01:35:03Z-
dc.date.issued2017-06-
dc.identifier.citationBIOCHIP JOURNAL, v. 11, no. 2, page. 109-115en_US
dc.identifier.issn1976-0280-
dc.identifier.issn2092-7843-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs13206-016-1203-7-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/114404-
dc.description.abstractThis paper presents a proof-of-concept microfluidic aptamer-based sensor for thrombin point of -care testing using electrochemical impedance spectroscopy. The disposable biosensor is composed of a polydimethylsiloxane (PDMS) channel layer over a glass substrate. The substrate surface has an Au working electrode and a Pt reference/counter electrode. In this study, human thrombin was used as a biomarker for disease diagnosis. An unlabeled aptamer specific to thrombin was immobilized on a working electrode and electrochemical impedance was measured as thrombin was injected into the biosensor. Thrombin was detected by measuring change in impedance. The proposed biochip had a detection range of 0.1-100,000 ng mL(-1) for thrombin concentration and a limit of detection of 0.1 ng mL(-1). The results indicated that our biochip could be an effective tool for other molecular diagnostic systems.en_US
dc.language.isoen_USen_US
dc.publisherKOREAN BIOCHIP SOCIETY-KBCSen_US
dc.subjectDNA Aptameren_US
dc.subjectMicrofluidicsen_US
dc.subjectThrombinen_US
dc.subjectElectrochemical impedance spectroscopyen_US
dc.subjectAnti-thrombin aptameren_US
dc.titleMicrofluidic biochips for simple impedimetric detection of thrombin based on label-free DNA aptamersen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume11-
dc.identifier.doi10.1007/s13206-016-1203-7-
dc.relation.page109-115-
dc.relation.journalBIOCHIP JOURNAL-
dc.contributor.googleauthorLimi, Taemin-
dc.contributor.googleauthorLee, Seung Yong-
dc.contributor.googleauthorYang, Jeongsuong-
dc.contributor.googleauthorHwang, Seung Yong-
dc.contributor.googleauthorAhn, Yoomin-
dc.relation.code2017004186-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidsyhwang-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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