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Correlations between Tumor to Background Ratio on Breast-Specific Gamma Imaging and Prognostic Factors in Breast Cancer

Title
Correlations between Tumor to Background Ratio on Breast-Specific Gamma Imaging and Prognostic Factors in Breast Cancer
Author
최윤영
Keywords
Breast Cancer; Gamma Camera Imaging; Tc-99m-sestaMIBI
Issue Date
2017-06
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v. 32, no. 6, page. 1031-1037
Abstract
The purpose of this study was to investigate the correlations between tumor-to-background ratio (TBR) obtained from breast-specific gamma imaging (BSGI) and the prognostic factors of breast cancer. Sixty-seven patients with invasive ductal carcinoma who underwent preoperative BSGI were enrolled. The BSGI images were visually scored from 1 to 5 according to a breast imaging reporting and data system (BIRADS). The TBR results obtained from positive BSGI images were compared according to the following prognostic factors: tumor size; axillary lymph node metastasis; nuclear grade (NG); histologic grade (HG); subtype; Ki-67; and the expression profile of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Among 67 images, 60 were classified as a positive finding (sensitivity 89.6%). A higher TBR value was significantly correlated with tumor size >= 2 cm (P= 0.001), axillary lymph node metastasis (P= 0.007), high HG (P= 0.029), negative PR status (P= 0.036), and Ki67 >= 14% (P= 0.007). The TBR showed a significant difference between the luminal A and non-luminal A subtypes (P= 0.007). On multivariate analysis, TBR had a high correlation with tumor size >= 2 cm, axillary lymph node metastasis, and negative PR status (P= 0.003, 0.048, and 0.030, respectively). A high TBR on BSGI was significantly correlated with poor prognostic factors of breast cancer. Luminal A subtype, a breast cancer subtype with more favorable prognosis, was associated with a low TBR on BSGI.
URI
https://jkms.org/DOIx.php?id=10.3346/jkms.2017.32.6.1031https://repository.hanyang.ac.kr/handle/20.500.11754/114368
ISSN
1011-8934; 1598-6357
DOI
10.3346/jkms.2017.32.6.1031
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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