110 38

Gestational Alcohol Exposure Altered DNA Methylation Status in the Developing Fetus

Title
Gestational Alcohol Exposure Altered DNA Methylation Status in the Developing Fetus
Author
채영규
Keywords
alcohol; epigenetics; DNA methylation; FASD; fetal development
Issue Date
2017-06
Publisher
MDPI AG
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 18, no. 7, Article no. 1386
Abstract
Ethanol is well known as a teratogenic factor that is capable of inducing a wide range of developmental abnormalities if the developing fetus is exposed to it. Duration and dose are the critical parameters of exposure that affect teratogenic variation to the developing fetus. It is suggested that ethanol interferes with epigenetic processes especially DNA methylation. We aimed to organize all of the available information on the alteration of DNA methylation by ethanol in utero. Thus, we have summarized all published information regarding alcohol-mediated alterations in DNA methylation during gestation. We tried to arrange information in a way that anyone can easily find the alcohol exposure time, doses, sampling time, and major changes in genomic level. Manuscript texts will also represent the correlation between ethanol metabolites and subsequent changes in methylome patterns. We hope that this review will help future researchers to further examine the issues associated with ethanol exposure.
URI
https://www.mdpi.com/1422-0067/18/7/1386https://repository.hanyang.ac.kr/handle/20.500.11754/114354
ISSN
1422-0067
DOI
10.3390/ijms18071386
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
Files in This Item:
Gestational Alcohol Exposure Altered DNA Methylation Status in the Developing Fetus.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE