Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이강녕 | - |
dc.date.accessioned | 2019-11-26T00:48:09Z | - |
dc.date.available | 2019-11-26T00:48:09Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.citation | MEDICINE, v. 96, no. 25, Article no. e7133 | en_US |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.issn | 1536-5964 | - |
dc.identifier.uri | https://insights.ovid.com/crossref?an=00005792-201706230-00016 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/114334 | - |
dc.description.abstract | Rationale: Recently tenofovir disoproxil fumarate (TDF) has been widely used as a first-line therapy for chronic hepatitis B (CHB) infection. Although TDF demonstrates successful viral suppression, the possibility of renal failure and lactic acidosis has been proposed with TDF administration, especially in human immunodeficiency virus co-infected patients. However, TDF induced lactic acidosis has never been reported in CHB mono-infected patients.Patient concerns: A 59-year-old man received TDF for hepatitis B associated with cirrhosis. After ten days of TDF administration, nausea, vomiting and abdominal pain developed. High anion gap acidosis with elevated lactate level (pH 7.341, pCO(2) 29.7 mmHg, HCO3-15.6mmHg, lactate 3.2mmol/L, anion gap 15.4 mEq/L) was developed.Diagnosis: With no infection, normal diagnostic paracentesis, and urinalysis together with high anion gap and increased blood lactate levels suggested lactic acidosis.Interventions: TDF was stopped, and haemodialysis was performed to control lactic acidosis.Outcomes: Although stopping TDF instantly and treating lactic acidosis using hemodialysis, the patient died.Lessons: Although, Fatal lactic acidosis is very rare in TDF patient, however, decompensated cirrhotic patients should be closely observed to keep the possibility of lactic acidosis in mind. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.subject | HBV | en_US |
dc.subject | lactic acidosis | en_US |
dc.subject | tenofovir disoproxil fumarate | en_US |
dc.title | Fatal lactic acidosis in hepatitis B virus-associated decompensated cirrhosis treated with tenofovir A case report | en_US |
dc.type | Article | en_US |
dc.relation.no | 25 | - |
dc.relation.volume | 96 | - |
dc.identifier.doi | 10.1097/MD.0000000000007133 | - |
dc.relation.page | 1-3 | - |
dc.relation.journal | MEDICINE | - |
dc.contributor.googleauthor | Jung, Tae Yang | - |
dc.contributor.googleauthor | Jun, Dae Won | - |
dc.contributor.googleauthor | Lee, Kang Nyeong | - |
dc.contributor.googleauthor | Lee, Hang Lak | - |
dc.contributor.googleauthor | Lee, Oh Young | - |
dc.contributor.googleauthor | Yoon, Byung Chul | - |
dc.contributor.googleauthor | Choi, Ho Soon | - |
dc.relation.code | 2017001922 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | leekn | - |
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