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Tumefactive Gallbladder Sludge at US: Prevalence and Clinical Importance

Title
Tumefactive Gallbladder Sludge at US: Prevalence and Clinical Importance
Author
김미미
Keywords
INTENSIVE-CARE-UNIT; BILIARY SLUDGE; DIFFERENTIAL-DIAGNOSIS; POLYPOID LESIONS; SONOGRAPHY; DISEASE; CANCER; ULTRASONOGRAPHY
Issue Date
2017-05
Publisher
RADIOLOGICAL SOC NORTH AMERICA
Citation
RADIOLOGY, v. 283, no. 2, page. 570-579
Abstract
Purpose: To evaluate the prevalence of tumefactive sludge of the gallbladder detected at ultrasonography (US) and to assess whether any clinical and imaging differences exist between benign and malignant tumefactive sludge.Materials and Methods: The institutional review board approved this retrospective study. The requirement for informed consent was waived. The study included a cohort (n = 6898) of patients with gallbladder sludge drawn from all adults (n = 115 178) who underwent abdominal US between March 2001 and March 2015. Tumefactive sludge was identified according to the following US findings: (a) nonmovable mass-like lesion and (b) absence of posterior acoustic shadowing at B-mode US and vascularity at color Doppler US. Follow- up examinations were arranged to ascertain whether the results showed true sludge or gallbladder cancer. Risk factors for malignant tumefactive sludge based on clinical and US characteristics were identified with multivariate logistic regression analysis.Results: The prevalence of gallbladder and tumefactive sludge at abdominal US during the observation period was 6.0% (6898 of 115 178) and 0.1% (135 of 115 178), respectively. Twenty-eight (20.7%) patients were lost to follow-up. Of the 107 with tumefactive sludge, 15 (14%) were confirmed to have malignant tumefactive sludge. The risk factors for malignant tumefactive sludge were old age (odds ratio [OR], 1.06; P =.035), female sex (OR, 5.48; P =.014), and absence of hyperechoic spots within the sludge (OR, 6.78; P =.008).Conclusion: Although the prevalence of tumefactive sludge at US was rare, a considerable proportion of patients had a malignancy. Careful follow-up is essential, especially for older patients, women, and those with an absence of hyperechoic spots at US.
URI
https://pubs.rsna.org/doi/10.1148/radiol.2016161042https://repository.hanyang.ac.kr/handle/20.500.11754/114202
ISSN
0033-8419
DOI
10.1148/radiol.2016161042
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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