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dc.contributor.author민경환-
dc.date.accessioned2019-11-25T07:15:15Z-
dc.date.available2019-11-25T07:15:15Z-
dc.date.issued2017-05-
dc.identifier.citationPATHOBIOLOGY, v. 84, no. 3, page. 130-138en_US
dc.identifier.issn1015-2008-
dc.identifier.issn1423-0291-
dc.identifier.urihttps://www.karger.com/Article/FullText/449428-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/114201-
dc.description.abstractBackground: Smad4 and GATA3 proteins are known prognostic markers in various cancers. Smad4 is a mediator linked to both tumour suppression and progression. GATA3 is a regulator of development and morphogenesis of the mammary gland. We assessed and compared the predictive performance of Smad4 and GATA3 for clinical outcomes in patients with breast cancer. Methods: The combined expression pattern based on Smad4+/- and GATA3+/- was evaluated by immunostaining using breast cancer tissue microarray, and the relationships between protein expression and clinicopathological variables were analysed. Results: Smad4 expression was only associated with an ill-defined tumour border, whereas GATA3 was associated with several good prognostic factors. On analysis of combined markers, there was a significant difference in the expression of fascin (an important factor for cancer invasiveness) between the Smad4+/GATA3- and Smad4-/GATA3+ groups. Smad4+/GATA3- was correlated with worse clinicopathological parameters, relapse-free survival (RFS), and overall survival (OS), compared to Smad4-/GATA3+. Conclusion: Combined markers of Smad4/GATA3 showed a superior performance compared to single markers for predicting RFS and OS in patients with breast cancer. (C) 2017 S. Karger AG, Baselen_US
dc.description.sponsorshipThis work was supported by Medical Research Funds from Kangbuk Samsung Hospital (No. HIY0150051).en_US
dc.language.isoen_USen_US
dc.publisherKARGERen_US
dc.subjectSmad4 proteinen_US
dc.subjectGATA3 proteinen_US
dc.subjectPrognosisen_US
dc.subjectBreast canceren_US
dc.titleExpression pattern of Smad4/GATA3 as a predictor of survival in invasive ductal carcinoma of the breasten_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume84-
dc.identifier.doi10.1159/000449428-
dc.relation.page130-138-
dc.relation.journalPATHOBIOLOGY-
dc.contributor.googleauthorMin, Kyueng-Whan-
dc.contributor.googleauthorKim, Dong-Hoon-
dc.contributor.googleauthorDo, Sung-Im-
dc.contributor.googleauthorChae, Seoung Wan-
dc.contributor.googleauthorKim, Kyungeun-
dc.contributor.googleauthorSohn, Jin Hee-
dc.contributor.googleauthorLee, Hyun Joo-
dc.contributor.googleauthorDo, In-Gu-
dc.contributor.googleauthorPyo, Jung-Soo-
dc.contributor.googleauthorKim, Yuil-
dc.relation.code2017002049-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidkyueng-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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