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Differential Prognostic Implications of Gastric Signet Ring Cell Carcinoma Stage Adjusted Analysis From a Single High-volume Center in Asia

Title
Differential Prognostic Implications of Gastric Signet Ring Cell Carcinoma Stage Adjusted Analysis From a Single High-volume Center in Asia
Author
박찬혁
Keywords
gastric cancer; prognostic factor; signet ring cell carcinoma
Issue Date
2017-05
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
ANNALS OF SURGERY, v. 265, no. 5, page. 946-953
Abstract
Objective: The aim of this study was to analyze the clinicopathologic characteristics and prognosis of signet ring cell carcinoma (SRC) according to disease status (early vs advanced gastric cancer) in gastric cancer patients.Background: The prognostic implication of gastric SRC remains a subject of debate.Methods: A retrospective analysis was performed using the clinical records of 7667 patients including 1646 SRC patients who underwent radical gastrectomy between 2001 and 2010. A further analysis was also performed after dividing patients into three groups according to histologic subtype: SRC, well-to-moderately differentiated (WMD), and poorly differentiated adenocarcinoma.Results: SRC patients have younger age distribution and female predominance compared with other histologic subtypes. Notably, the distribution of T stage of SRC patients was distinct, located in extremes (T1: 66.2% and T4: 20%). Moreover, the prognosis of SRC in early gastric cancer and advanced gastric cancer was contrasting. In early gastric cancer, SRC demonstrated more favorable prognosis than WMD after adjusting for age, sex, and stage. In contrast, SRC in advanced gastric cancer displayed worse prognosis than WMD. As stage increased, survival outcomes of SRC continued to worsen compared with WMD.Conclusions: Although conferring favorable prognosis in early stage, SRC has worse prognostic impact as disease progresses. The longstanding controversy of SRC on prognosis may result from disease status at presentation, which leads to differing prognosis compared with tubular adenocarinoma.
URI
https://insights.ovid.com/crossref?an=00000658-201705000-00017https://repository.hanyang.ac.kr/handle/20.500.11754/114196
ISSN
0003-4932; 1528-1140
DOI
10.1097/SLA.0000000000001793
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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