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Efficacy and safety of early supplementation with 800 IU of vitamin D in very preterm infants followed by underlying levels of vitamin D at birth

Title
Efficacy and safety of early supplementation with 800 IU of vitamin D in very preterm infants followed by underlying levels of vitamin D at birth
Author
박현경
Keywords
Vitamin D; Supplementation; Premature infants; Follow-up; DXA
Issue Date
2017-05
Publisher
BIOMED CENTRAL LTD
Citation
ITALIAN JOURNAL OF PEDIATRICS, v. 43, Article no. 45
Abstract
Background: To determine the efficacy and safety of early supplementation with 800 IU of vitamin D in very low birth weight (VLBW) infants.Methods: Sixty-six infants with a birth weight less than 1500 g admitted to the Neonatal Intensive Care Unit. Of these, 52 infants were eligible and received 800 IU/day vitamin D from 2 weeks of age. We examined 25-hydroxyvitamin-D (25[OH] D) levels from cord blood at birth and serum at 32 and 36 weeks of postmenstrual age.Results: The study infants were divided by cord-blood levels of 25(OH) D at birth into 25(OH) D concentrations < 10 ng/mL (n = 20) or >= 10 ng/mL (n = 29). Vitamin D intake of 800 IU/day safely achieved an 88% probability of vitamin D sufficiency at 36 weeks postmenstrual age in VLBW infants with cord-blood levels of 25(OH) D >= 10 ng/mL, and 65% probability of vitamin D sufficiency was observed in infants with 25 OHD concentrations < 10 ng/mL at birth.Conclusion: Considering the efficacy and safety of vitamin D supplementation in this study, vitamin D intake of 800 IU/day may enhance vitamin D status during early hospitalization in VLBW infants with 25 OHD concentrations < 10 ng/mL at birth. The clinical significance of optimal vitamin D intake in VLBW infants needs to be studied in larger controlled studies.
URI
https://ijponline.biomedcentral.com/articles/10.1186/s13052-017-0361-0https://repository.hanyang.ac.kr/handle/20.500.11754/114162
ISSN
1720-8424; 1824-7288
DOI
10.1186/s13052-017-0361-0
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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