73 0

Treatment Patterns and Patient Reported Outcomes in Benign Prostatic Hyperplasia Patients with Overactive Bladder Symptoms

Title
Treatment Patterns and Patient Reported Outcomes in Benign Prostatic Hyperplasia Patients with Overactive Bladder Symptoms
Author
이승욱
Keywords
benign prostatic hyperplasia; clinical outcomes; overactive bladder symptoms; patient-reported outcomes; treatment pattern
Issue Date
2017-05
Publisher
WILEY
Citation
LUTS-LOWER URINARY TRACT SYMPTOMS, v. 9, no. 2, page. 75-81
Abstract
ObjectivesWe aimed to examine the treatment patterns, and patient-reported outcomes (PROs) in benign prostatic hyperplasia (BPH) patients with overactive bladder (OAB) symptoms.MethodsSeven hundred and forty seven patients were included in this prospective observational study. The primary endpoint was to describe the medical treatment patterns for BPH patients with OAB symptoms. The secondary endpoint was to determine the PROs of these patients. Clinical outcome was assessed using International prostate symptom score (IPSS), and PROs were measured using BPH-Related QoL Questionnaire Korea 1 (BPH QoL K1) and Euroqol-5 Dimension (EQ-5D).ResultsWhen starting the study, 391 patients (52.3%) received -blocker monotherapy, whereas 356 (47.7%) received combination therapy with anticholinergics. Of the 369 patients who completed the 6-month treatment, 139 patients (37.7%) still received -blocker monotherapy, 122 (33.1%) still received combination therapy with anticholinergics, and 108 (29.3%) received subsequent anticholinergics in addition to -blocker. When the patients were stratified, storage subscore was higher (9.5 vs. 8.8, P=0.034) and voiding subscore (9.7 vs. 11.6, P=0.001) was lower in patients with anticholinergics than those without it. Although all treatment groups reported a significant improvement from baseline, no significant between-group differences in changes in IPSS, EQ-5D and BPH QoL K1 was found.ConclusionsAbout one-third of patients received -blocker monotherapy, one-third received combination therapy with anticholinergics, and another one-third received subsequent anticholinergics in addition to -blocker. Storage subscore was higher in patients with anticholinergics than those without it, but vice-versa for voiding subscore. Similar improvement on clinical outcomes and PROs was observed in all treatment groups.
URI
https://onlinelibrary.wiley.com/doi/abs/10.1111/luts.12112https://repository.hanyang.ac.kr/handle/20.500.11754/114156
ISSN
1757-5664; 1757-5672
DOI
10.1111/luts.12112
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE