Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최찬범 | - |
dc.date.accessioned | 2019-11-25T04:09:30Z | - |
dc.date.available | 2019-11-25T04:09:30Z | - |
dc.date.issued | 2017-05 | - |
dc.identifier.citation | LUPUS, v. 26, no. 6, page. 598-605 | en_US |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.issn | 1477-0962 | - |
dc.identifier.uri | https://journals.sagepub.com/doi/10.1177/0961203316671813 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/114036 | - |
dc.description.abstract | Objective The objective of this study was to investigate the association of lupus nephritis on organ damage and mortality in patients with systemic lupus erythematosus (SLE).Methods A total of 1112 patients with SLE were investigated. Lupus nephritis was defined as a proteinuria based on the 1997 American College of Rheumatology criteria. Damage was assessed using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. The associations of lupus nephritis with overall, non-renal, corticosteroid-associated, and non-associated damage were analyzed using logistic regression. The age-adjusted and sex-adjusted standardized mortality ratio was evaluated in patients with and without lupus nephritis.Results The prevalence of lupus nephritis in patients with SLE was 46.3%. Patients with lupus nephritis had a higher percentage of overall cumulative damage than patients without lupus nephritis (51.5% vs. 35.7%, p<0.001). The odds ratio was 1.40 after adjusting for age at SLE diagnosis, sex, disease duration, anti-malarial agents, immunosuppressive agents and cumulative corticosteroid dose. Among non-renal damage, the odds of corticosteroid-associated damage were higher (2.06, 95% confidence interval (CI) 1.43-2.96) whereas the odds of non-associated damage were lower (0.50, 95% CI 0.35-0.75) in patients with lupus nephritis. The standardized mortality ratios of patients with and without lupus nephritis were 5.17 (95% CI 3.49-7.38) and 2.32 (95% CI 1.47-3.48), respectively.Conclusion In patients with SLE, the presence of lupus nephritis is associated with increased corticosteroid-associated damage but less corticosteroid non-associated damage. Also, mortality is significantly higher in patients with lupus nephritis than in those without lupus nephritis. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SAGE PUBLICATIONS LTD | en_US |
dc.subject | Systemic lupus erythematosus | en_US |
dc.subject | lupus nephritis | en_US |
dc.subject | organ damage | en_US |
dc.subject | corticosteroid | en_US |
dc.title | Lupus nephritis is associated with more corticosteroid-associated organ damage but less corticosteroid non-associated organ damage | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 26 | - |
dc.identifier.doi | 10.1177/0961203316671813 | - |
dc.relation.page | 598-605 | - |
dc.relation.journal | LUPUS | - |
dc.contributor.googleauthor | Joo, Y. B. | - |
dc.contributor.googleauthor | Won, S. | - |
dc.contributor.googleauthor | Choi, C-B | - |
dc.contributor.googleauthor | Bae, S-C | - |
dc.relation.code | 2017003718 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | cbchoi | - |
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