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Potential of synthetic endoperoxides against Trichomonas vaginalis in vitro

Title
Potential of synthetic endoperoxides against Trichomonas vaginalis in vitro
Author
류재숙
Keywords
Trichomonas vaginalis; 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89); 6-(1,2,6,7-Tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251); Anti-trichomonal activity; Endoperoxides; Metronidazole-resistant isolate
Issue Date
2017-05
Publisher
ELSEVIER IRELAND LTD
Citation
PARASITOLOGY INTERNATIONAL, v. 66, no. 5, page. 619-621
Abstract
Metronidazole is well known for medicine against Trichomonas vaginalis infection, but it has side effects though it is effective, and especially because reports of metronidazole-tolerant species are increasing, the development of new medicine is being required. Here, we noticed the killing effects of endoperoxide compounds, N-89 and N-251 as new antimalarial drug candidates, on T. vaginalis and searched the possibility of development of new medicine. We added each of metronidazole, artemisinin, and two of new endoperoxides (N-89 and N-251) to metronidazole-resistant and -sensitive species and compared its anti-trichomonal efficacy. For metronidazole, IC50 value, 50% of killing concentration for T. vaginalis, was very low for metronidazole-sensitive isolates (11.7 to 22.8 mu M), but was high for metronidazole-resistant ones (182.9 to 730.4 mu M). The IC50 values of N-89 and N-251 were 41.0 to 60.0 mu M, and 82.0 to 300.0 mu M for metronidazole-sensitive and-resistant isolates, respectively. In conclusion, we found the endoperoxides, N-89 and N-251, have anti-trichomonal effect against metronidazole-resistant T. vaginalis as well as metronidazole-sensitive ones. These results indicate that the anti-richomonal effects for our endoperoxides are equivalent or better in metronidazole-resistant T. vaginalis in comparison to metronidazole.
URI
https://www.sciencedirect.com/science/article/pii/S1383576917301824?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/114004
ISSN
1383-5769
DOI
10.1016/j.parint.2017.05.008
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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