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Tumor necrosis and complete resection has significant impacts on survival in patients with limited-stage upper aerodigestive tract NK/T cell lymphoma

Title
Tumor necrosis and complete resection has significant impacts on survival in patients with limited-stage upper aerodigestive tract NK/T cell lymphoma
Author
송무곤
Keywords
extranodal natural killer/T-cell lymphoma; tumor necrosis; complete resection; prognosis
Issue Date
2017-05
Publisher
IMPACT JOURNALS LLC
Citation
ONCOTARGET, v. 8, no. 45, page. 79337-79346
Abstract
Tumor necrosis (TN) is associated with worse prognosis in several solid cancers. Whether TN predicts poor outcome in natural killer cell / T cell lymphoma (NKTCL) is unclear. We investigated the clinical impact of TN on survival and other novel prognostic parameters in upper aero-digestive tract (UAT) NKTCL of 100 patients with limited stage. TN was significantly associated with poor performance status (p = 0.049), high Korean Prognostic Index score (p = 0.024), high C-reactive protein/albumin ratio (p = 0.003), higher maximum standard uptake value on positron emission tomography/computed tomography (PET/CT) (p = 0.008) and higher metabolic tumor volume (MTV) on PET/CT (p < 0.001). In univariate and multivariate analyses, progression-free survival and overall survival were independently associated with High MTV status (p = 0.001, p = 0.032), TN (p = 0.018, p = 0.009), local tumor invasiveness (p = 0.007, p = 0.035), complete resection (p = 0.020, p = 0.028) and regional lymph node involvement (p < 0.001, p < 0.001). TN and complete resection are concluded to be novel independent prognostic factors in patients with UAT NKTCL.
URI
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=18107&path[]=58023https://repository.hanyang.ac.kr/handle/20.500.11754/113994
ISSN
1949-2553
DOI
10.18632/oncotarget.18107
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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