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dc.contributor.author이근용-
dc.date.accessioned2019-11-25T01:15:47Z-
dc.date.available2019-11-25T01:15:47Z-
dc.date.issued2017-05-
dc.identifier.citationCOLLOIDS AND SURFACES B-BIOINTERFACES, v. 155, page. 229-237en_US
dc.identifier.issn0927-7765-
dc.identifier.issn1873-4367-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0927776517302011?via%3Dihub-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/113938-
dc.description.abstractControl of stem cell fate and phenotype using biomimetic synthetic extracellular matrices (ECMs) is an important tissue engineering approach. Many studies have focused on improving cell-matrix interactions. However, proper control of cell-cell interactions using synthetic ECMs could be critical for tissue engineering, especially with undifferentiated stem cells. In this study, alginate hydrogels were modified with a peptide derived from the low-density lipoprotein receptor-related protein 5 (LRP5), which is known to bind to N-cadherin, as a cell-cell interaction motif. In vitro changes in the morphology and differentiation of mouse bone marrow stromal cells (D1 stem cells) cultured in LRP5-alginate hydrogels were investigated. LRP5-alginate gels successfully induced stem cell aggregation and enhanced chondrogenic differentiation of Dl stem cells, compared to RGD-alginate gels, at low cell density. This approach to tailoring synthetic biomimetic ECM5 using cell-cell interaction motifs may be critical in tissue engineering approaches using stem cells. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis research was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI13C1940). This work was also supported by a National Research Foundation of Korea (NRF) grant funded by the Ministry of Science, ICT & Future Planning (MSIP) (NRF-2016R1A2A2A10005086).en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectCell-cell interactionen_US
dc.subjectLow-density lipoprotein receptor-related protein 5en_US
dc.subjectN-cadherinen_US
dc.subjectStem cellen_US
dc.subjectAlginate hydrogelen_US
dc.titleIntroduction of N-cadherin-binding motif to alginate hydrogels for controlled stem cell differentiationen_US
dc.typeArticleen_US
dc.relation.volume155-
dc.identifier.doi10.1016/j.colsurfb.2017.04.014-
dc.relation.page229-237-
dc.relation.journalCOLLOIDS AND SURFACES B-BIOINTERFACES-
dc.contributor.googleauthorLee, Jae Won-
dc.contributor.googleauthorAn, Hyoseok-
dc.contributor.googleauthorLee, Kuen Yong-
dc.relation.code2017001472-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF BIOENGINEERING-
dc.identifier.pidleeky-
dc.identifier.orcidhttp://orcid.org/0000-0002-5759-5952-
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COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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