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Interaction between Trichomonas vaginalis and the Prostate Epithelium

Title
Interaction between Trichomonas vaginalis and the Prostate Epithelium
Author
한익환
Keywords
Trichomonas vaginalis; epithelial cell; cell adhesion; inflammation
Issue Date
2017-04
Publisher
KOREAN SOC PARASITOLOGY
Citation
KOREAN JOURNAL OF PARASITOLOGY, v. 55, no. 2, page. 213-218
Abstract
Most men infected with Trichomonas vaginalis are asymptomatic and can remain undiagnosed and untreated. This has been hypothesized to result in chronic persistent prostatic infection. Adhesion of the protozoan organisms to mucosal cells is considered a first and prerequisite step for T. vaginalis infection. Adhesion of T. vaginalis to prostate epithelial cells has not yet been observed; however, there are several reports about inflammation of prostate epithelial cells induced by T. vaginalis. The aim of this study was to investigate whether adhesion and cytotoxicity of T. vaginalis are involved in inflammation of prostate epithelial cells. When RWPE-1 cells were infected with T. vaginalis (1:0.4 or 1:4), adhesion of T. vaginalis continuously increased for 24 hr or 3 hr, respectively. The cytotoxicity of prostate epithelial cells infected with T. vaginalis (RWPE-1: T. vaginalis=1:0.4) increased at 9 hr; at an infection ratio of 1:4, cytotoxicity increased after 3 hr. When the RWPE-1 to T. vaginalis ratio was 1:0.4 or 1:4, production of IL-1β, IL-6, CCL2, and CXCL8 also increased. Epithelial-mesenchymal transition (EMT) was verified by measuring decreased E-cadherin and increased vimentin expression at 24 hr and 48 hr. Taken together, the results indicate that T. vaginalis adhered to prostate epithelial cells, causing cytotoxicity, pro-inflammatory cytokine production, and EMT. Our findings suggest for the first time that T. vaginalis may induce inflammation via adhesion to normal prostate epithelial cells.
URI
http://parasitol.kr/journal/view.php?doi=10.3347/kjp.2017.55.2.213https://repository.hanyang.ac.kr/handle/20.500.11754/113863
ISSN
0023-4001; 1738-0006
DOI
10.3347/kjp.2017.55.2.213
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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