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Development of chitosan nanocapsules for the controlled release of hexaconazole

Title
Development of chitosan nanocapsules for the controlled release of hexaconazole
Author
김기현
Keywords
Nanotechnology; Chitosan; Hexaconazole; Controlled release; lonotropic gelation; Fungicide
Issue Date
2017-04
Publisher
ELSEVIER SCIENCE BV
Citation
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v. 97, page. 616-624
Abstract
Accelerated use of pesticides in cutting edge agriculture prompted us to explore smart nanoformulations to subside the consumption of these perilous chemicals. Polymer nanocapsules carrying a fungicide, hexaconazole were developed through ionotropic gelation method utilizing chitosan and tripolyphosphate (TPP). The nanocapsules were characterized by photon correlation spectroscope (PCS), transmission electron microscope (TEM), and Fourier transform infra-red (FTIR) spectroscope. Nanocapsules were optimized for size and high encapsulation efficiency using central composite design (CCD) software. The encapsulation efficiency of nanocapsules for hexaconazole was 73% as assessed by gas chromatography (GC). Nanocapsules were analysed and compared with commercial formulation for controlled release in vitro at three different pH values. Release of hexaconazole from nanocapsules was fastest at pH 4 in comparison to pH 7 and pH 10. Release study in soil was also conducted and revealed a controlled pattern for nanoformulation. The fungicidal activity of the prepared nanoformulation was evaluated against R. solani and was compared with commercial formulation of hexaconazole. The cytotoxicity assay performed on vero cell lines by MTT(3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay confirmed that nanoformulation is less toxic than commercial formulation of pesticide. (C) 2016 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0141813016310327?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/113848
ISSN
0141-8130; 1879-0003
DOI
10.1016/j.ijbiomac.2016.12.059
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > CIVIL AND ENVIRONMENTAL ENGINEERING(건설환경공학과) > Articles
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