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Peri-pubertal high caffeine exposure increases ovarian estradiol production in immature rats

Title
Peri-pubertal high caffeine exposure increases ovarian estradiol production in immature rats
Author
배재만
Keywords
Caffeine; Puberty; Ovary; Estrogen; Aromatase; Uterus; Estrogen receptor; Rat
Issue Date
2017-04
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
REPRODUCTIVE TOXICOLOGY, v. 69, page. 43-52
Abstract
Chronic caffeine consumption exerts a negligible effect on the reproductive organs of normal adult females, but it is not known whether this is also true for children and adolescents. Here, we investigated the effects of high caffeine exposure on sexual maturation and ovarian estradiol production in immature female rats. Immature female SD rats were divided into controls and caffeine groups fed 120 and 180 mg/kg/day for 4 or 8 weeks. There was a significant delay in vaginal opening in the caffeine fed groups. In addition, serum estradiol levels were elevated in the caffeine-fed animals after 2 and 4 weeks of exposure. Estradiol secretion as well as aromatase expression also increased significantly in the ovarian cells in response to caffeine. These results demonstrate that peripubertal exposure to high caffeine increases estradiol production in the ovary; this may disturb the coordinated regulation of the hypothalamo-pituitary-ovarian axis, thereby interfering with sexual maturation. (C) 2017 Elsevier Inc. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0890623817300217?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/113773
ISSN
0890-6238
DOI
10.1016/j.reprotox.2017.01.007
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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