Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김교상 | - |
dc.date.accessioned | 2019-11-24T17:24:25Z | - |
dc.date.available | 2019-11-24T17:24:25Z | - |
dc.date.issued | 2017-04 | - |
dc.identifier.citation | KOREAN JOURNAL OF ANESTHESIOLOGY, v. 70, no. 2, page. 203-208 | en_US |
dc.identifier.issn | 2005-6419 | - |
dc.identifier.issn | 2005-7563 | - |
dc.identifier.uri | https://ekja.org/journal/view.php?doi=10.4097/kjae.2017.70.2.203 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/113767 | - |
dc.description.abstract | Background: Magnesium sulfate (MgSO4) has been used in the treatment of pre-eclampsia, hypertension and arrhythmia. Magnesium enhances the neuromuscular block of rocuronium. This study has been conducted to evaluate the reversal efficacy of sugammadex from deep rocuronium-induced neuromuscular block (NMB) during consistent pretreatment of MgSO4 in rabbits.Methods: Twenty-eight rabbits were randomly assigned to four groups, a control group or study groups (50% MgSO4 150-200 mg/kg and 25 mg/kg/h IV), and received rocuronium 0.6 mg/kg. When post-tetanic count 1-2 appeared, sugammadex 2, 4, and 8 mg/kg was administered in the 2-mg group, control and 4-mg group, and 8-mg group, respectively. The recovery course after reversal of sugammadex administration was evaluated in each group.Results: The mean serum concentration of magnesium was maintained at more than 2 mmol/L in the study groups, and the total dose of MgSO4 was more than 590 mg. The reversal effect of sugammadex on rocuronium-induced NMB in pretreated MgSO4 was not different from that in the group without MgSO4. The recovery time to train-of-four ratio 0.9 after sugammadex administration in the 2-mg group was longer than in the other groups (P < 0.001); there were no other significant differences among the groups.Conclusions: The reversal of sugammadex from a deep rocuronium-induced NMB during large pretreatment of MgSO4 was not affected. However, we should consider that the reversal effect of sugammadex varied depending on the dose. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN SOC ANESTHESIOLOGISTS | en_US |
dc.subject | Magnesium sulfate | en_US |
dc.subject | Pharmacodynamics | en_US |
dc.subject | Rabbits | en_US |
dc.subject | Rocuronium | en_US |
dc.subject | Sugammadex | en_US |
dc.title | Reversal with sugammadex for rocuronium-induced deep neuromuscular block after pretreatment of magnesium sulfate in rabbits | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 70 | - |
dc.identifier.doi | 10.4097/kjae.2017.70.2.203 | - |
dc.relation.page | 203-208 | - |
dc.relation.journal | Korean Journal of Anesthesiology | - |
dc.contributor.googleauthor | Kang, Woon Seok | - |
dc.contributor.googleauthor | Kim, Kyo Sang | - |
dc.contributor.googleauthor | Song, Shin Mi | - |
dc.relation.code | 2017034545 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kimks | - |
dc.identifier.orcid | http://orcid.org/0000-0002-2186-3484 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.