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Two arms hydrophilic photosensitizer conjugates with vitamin B for cancer-selective photodynamic therapy

Title
Two arms hydrophilic photosensitizer conjugates with vitamin B for cancer-selective photodynamic therapy
Author
정재윤
Keywords
cancer selective; photodynamic therapy; hydrophilic photosensitizer; vitamin B; theranostic
Issue Date
2017-04
Publisher
WILEY
Citation
POLYMERS FOR ADVANCED TECHNOLOGIES, v. 28, no. 4, page. 443-448
Abstract
Cancer-selective internalization has a great potential for reducing the side effect of photodynamic therapy. Recently, various cancer-targeted delivery carriers have provided enhanced cancer targeting efficiency. Despite significant advancements in cancer-targeted carriers, side effects are still present because of non-selective cellular uptake that occurs in the heterogeneous cancer environment. In this paper, we designed two types of cancer-selectable two arm hydrophilic photosensitizer (CTAHP2K and CTAHP4K) with silicon-tetrapyrazinoporphyrazines (ST), polyethylene glycol and the cancer-specific ligand for cancer-selective theranostics. The synthesized CTAHP4K exhibits a folate receptor-mediated cancer-selective cellular uptake and induces cancer-selective death. The folate receptor-mediated cancer-selective internalization of CTAHP4K was confirmed by competitive interaction with vitamin B in MDA-MB-231 human breast carcinoma. The cancer-selective cytotoxicity of CTAHP4K was confirmed using a 670-nm laser to irradiate Chang Liver cells and MDA-MB-231 cells. Copyright (c) 2016 John Wiley & Sons, Ltd.
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/pat.3904https://repository.hanyang.ac.kr/handle/20.500.11754/113742
ISSN
1042-7147; 1099-1581
DOI
10.1002/pat.3904
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ORGANIC AND NANO ENGINEERING(유기나노공학과) > Articles
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