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dc.contributor.author김찬형-
dc.date.accessioned2019-11-24T16:20:18Z-
dc.date.available2019-11-24T16:20:18Z-
dc.date.issued2017-04-
dc.identifier.citationJOURNAL OF THE KOREAN PHYSICAL SOCIETY, v. 70, no. 7, page. 720-725en_US
dc.identifier.issn0374-4884-
dc.identifier.issn1976-8524-
dc.identifier.urihttps://link.springer.com/article/10.3938%2Fjkps.70.720-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/113726-
dc.description.abstractIn proton therapy, the spot scanning method is known to suffer from the interplay effect induced from the independent movements of the proton beam and the organs in the patient during the treatment. To study the interplay effect, several investigators have performed four-dimensional (4D) dose calculations with some limited temporal resolutions (4 or 10 phases per respiratory cycle) by using the 4D computed tomography (CT) images of the patient; however, the validity of the limited temporal resolutions has not been confirmed. The aim of the present study is to determine whether the previous temporal resolutions (4 or 10 phases per respiratory cycle) are really high enough for adequate study of the interplay effect in spot scanning proton therapy. For this study, a series of 4D dose calculations were performed with a virtual water phantom moving in the vertical direction during dose delivery. The dose distributions were calculated for different temporal resolutions (4, 10, 25, 50, and 100 phases per respiratory cycle), and the calculated dose distributions were compared with the reference dose distribution, which was calculated using an almost continuously-moving water phantom (i.e., 1000 phases per respiratory cycle). The results of the present study show that the temporal resolutions of 4 and 10 phases per respiratory cycle are not high enough for an accurate evaluation of the interplay effect for spot scanning proton therapy. The temporal resolution should be at least 14 and 17 phases per respiratory cycle for 10-mm and 20-mm movement amplitudes, respectively, even for rigid movement (i.e., without deformation) of the homogeneous water phantom considered in the present study. We believe that even higher temporal resolutions are needed for an accurate evaluation of the interplay effect in the human body, in which the organs are inhomogeneous and deform during movement.en_US
dc.description.sponsorshipThis project was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, by the Nuclear Safety Research and Development (NSR&D) Program through the Korea Foundation of Nuclear Safety (KoFONS) funded by Nuclear Safety and Security Commission (NSSC), and by the Electronics and Telecommunications Research Institute (ETRI) R&D program funded by the Ministry of Science, ICT, and Future Planning (Project Nos.: 2016R1D1A1A09916337, 1403012, 15ZC1810).en_US
dc.language.isoen_USen_US
dc.publisherKOREAN PHYSICAL SOCen_US
dc.subjectProton therapyen_US
dc.subjectSpot scanningen_US
dc.subjectInterplay effecten_US
dc.subjectTemporal resolutionen_US
dc.titleTemporal resolution required for accurate evaluation of the interplay effect in spot scanning proton therapyen_US
dc.typeArticleen_US
dc.relation.no7-
dc.relation.volume70-
dc.identifier.doi10.3938/jkps.70.720-
dc.relation.page720-725-
dc.relation.journalJOURNAL OF THE KOREAN PHYSICAL SOCIETY-
dc.contributor.googleauthorSeo, Jeongmin-
dc.contributor.googleauthorHan, Min Cheol-
dc.contributor.googleauthorYeom, Yeon Soo-
dc.contributor.googleauthorLee, Hyun Su-
dc.contributor.googleauthorKim, Chan Hyeong-
dc.contributor.googleauthorJeong, Jong Hwi-
dc.contributor.googleauthorKim, SeongHoon-
dc.relation.code2017000496-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF NUCLEAR ENGINEERING-
dc.identifier.pidchkim-
dc.identifier.researcherIDK-6214-2017-
dc.identifier.orcidhttp://orcid.org/0000-0002-0667-0481-
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > NUCLEAR ENGINEERING(원자력공학과) > Articles
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